Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. |
Domain |
PF01217 Clathrin adaptor complex small chain |
Function |
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. |
Biological Process |
GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002697 regulation of immune effector process GO:0002831 regulation of response to biotic stimulus GO:0006898 receptor-mediated endocytosis GO:0007018 microtubule-based movement GO:0007164 establishment of tissue polarity GO:0007173 epidermal growth factor receptor signaling pathway GO:0009615 response to virus GO:0016055 Wnt signaling pathway GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0030100 regulation of endocytosis GO:0035567 non-canonical Wnt signaling pathway GO:0038127 ERBB signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0048002 antigen processing and presentation of peptide antigen GO:0048013 ephrin receptor signaling pathway GO:0048268 clathrin coat assembly GO:0050688 regulation of defense response to virus GO:0050690 regulation of defense response to virus by virus GO:0050792 regulation of viral process GO:0051607 defense response to virus GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060627 regulation of vesicle-mediated transport GO:0072583 clathrin-dependent endocytosis GO:0090175 regulation of establishment of planar polarity GO:0098542 defense response to other organism GO:0198738 cell-cell signaling by wnt GO:1901184 regulation of ERBB signaling pathway GO:1901185 negative regulation of ERBB signaling pathway GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis |
Molecular Function |
GO:0008565 protein transporter activity GO:0030276 clathrin binding GO:0030674 protein binding, bridging GO:0035615 clathrin adaptor activity GO:0060090 binding, bridging GO:0098748 endocytic adaptor activity |
Cellular Component |
GO:0005765 lysosomal membrane GO:0005905 clathrin-coated pit GO:0010008 endosome membrane GO:0030117 membrane coat GO:0030118 clathrin coat GO:0030119 AP-type membrane coat adaptor complex GO:0030120 vesicle coat GO:0030122 AP-2 adaptor complex GO:0030125 clathrin vesicle coat GO:0030128 clathrin coat of endocytic vesicle GO:0030131 clathrin adaptor complex GO:0030132 clathrin coat of coated pit GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0036019 endolysosome GO:0036020 endolysosome membrane GO:0044440 endosomal part GO:0045334 clathrin-coated endocytic vesicle GO:0048475 coated membrane GO:0098589 membrane region GO:0098852 lytic vacuole membrane |
KEGG |
hsa04144 Endocytosis hsa04721 Synaptic vesicle cycle hsa04961 Endocrine and other factor-regulated calcium reabsorption |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928665: EPH-ephrin mediated repulsion of cells R-HSA-399721: Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity R-HSA-162906: HIV Infection R-HSA-162909: Host Interactions of HIV factors R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-373760: L1CAM interactions R-HSA-171052: LDL-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-2132295: MHC class II antigen presentation R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-167590: Nef Mediated CD4 Down-regulation R-HSA-182218: Nef Mediated CD8 Down-regulation R-HSA-164938: Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-4086400: PCP/CE pathway R-HSA-437239: Recycling pathway of L1 R-HSA-177504: Retrograde neurotrophin signalling R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-166520: Signalling by NGF R-HSA-164952: The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-399719: Trafficking of AMPA receptors R-HSA-416993: Trafficking of GluR2-containing AMPA receptors R-HSA-112315: Transmission across Chemical Synapses R-HSA-8855121: VLDL interactions R-HSA-8866427: VLDLR internalisation and degradation R-HSA-5653656: Vesicle-mediated transport R-HSA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5099900: WNT5A-dependent internalization of FZD4 |
Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AP2S1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AP2S1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AP2S1 in various data sets.
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Points in the above scatter plot represent the mutation difference of AP2S1 in various data sets.
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Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AP2S1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AP2S1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AP2S1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AP2S1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AP2S1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AP2S1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | AP2S1 |
Name | adaptor-related protein complex 2, sigma 1 subunit |
Aliases | FBHOk; FBH3; CLAPS2; HHC3; hypocalciuric hypercalcemia 3 (Oklahoma type); AP17; HA2 17 kDa subunit; adaptor ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AP2S1 collected from DrugBank database. |
There is no record. |