Browse AP3D1

Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side
Domain PF01602 Adaptin N terminal region
Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).

> Gene Ontology
 
Biological Process GO:0001865 NK T cell differentiation
GO:0002475 antigen processing and presentation via MHC class Ib
GO:0002521 leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0006726 eye pigment biosynthetic process
GO:0006875 cellular metal ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0007018 microtubule-based movement
GO:0007034 vacuolar transport
GO:0007159 leukocyte cell-cell adhesion
GO:0008088 axo-dendritic transport
GO:0008089 anterograde axonal transport
GO:0010970 transport along microtubule
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0019882 antigen processing and presentation
GO:0019884 antigen processing and presentation of exogenous antigen
GO:0021700 developmental maturation
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0032119 sequestering of zinc ion
GO:0032438 melanosome organization
GO:0032844 regulation of homeostatic process
GO:0033059 cellular pigmentation
GO:0035646 endosome to melanosome transport
GO:0042110 T cell activation
GO:0042440 pigment metabolic process
GO:0042441 eye pigment metabolic process
GO:0043324 pigment metabolic process involved in developmental pigmentation
GO:0043473 pigmentation
GO:0043474 pigment metabolic process involved in pigmentation
GO:0043476 pigment accumulation
GO:0043482 cellular pigment accumulation
GO:0043485 endosome to pigment granule transport
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045785 positive regulation of cell adhesion
GO:0046148 pigment biosynthetic process
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0046634 regulation of alpha-beta T cell activation
GO:0046635 positive regulation of alpha-beta T cell activation
GO:0046637 regulation of alpha-beta T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046916 cellular transition metal ion homeostasis
GO:0047496 vesicle transport along microtubule
GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048066 developmental pigmentation
GO:0048069 eye pigmentation
GO:0048489 synaptic vesicle transport
GO:0048490 anterograde synaptic vesicle transport
GO:0048499 synaptic vesicle membrane organization
GO:0048753 pigment granule organization
GO:0048757 pigment granule maturation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050931 pigment cell differentiation
GO:0051136 regulation of NK T cell differentiation
GO:0051138 positive regulation of NK T cell differentiation
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0055069 zinc ion homeostasis
GO:0055076 transition metal ion homeostasis
GO:0061088 regulation of sequestering of zinc ion
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071593 lymphocyte aggregation
GO:0072384 organelle transport along microtubule
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072657 protein localization to membrane
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0098930 axonal transport
GO:0099514 synaptic vesicle cytoskeletal transport
GO:0099517 synaptic vesicle transport along microtubule
GO:0099518 vesicle cytoskeletal trafficking
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:2000021 regulation of ion homeostasis
Molecular Function -
Cellular Component GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
GO:0030117 membrane coat
GO:0030119 AP-type membrane coat adaptor complex
GO:0030123 AP-3 adaptor complex
GO:0030424 axon
GO:0032838 cell projection cytoplasm
GO:0033267 axon part
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0044306 neuron projection terminus
GO:0044440 endosomal part
GO:0048475 coated membrane
GO:0098793 presynapse
GO:0098852 lytic vacuole membrane
GO:0099568 cytoplasmic region
GO:1904115 axon cytoplasm
> KEGG and Reactome Pathway
 
KEGG hsa04142 Lysosome
Reactome -
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AP3D1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AP3D1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AP3D1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.120.59
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1780.945
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0760.968
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.190.51
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1270.962
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2710.937
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0450.917
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1230.95
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2660.901
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.290.863
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6320.796
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0370.423
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AP3D1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141728.6028.60.0318
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103300300.528
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AP3D1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AP3D1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AP3D1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AP3D1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AP3D1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AP3D1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAP3D1
Nameadaptor-related protein complex 3, delta 1 subunit
Aliases ADTD; hBLVR; AP-3 complex delta subunit, partial CDS; AP-3 complex subunit delta; adapter-related protein co ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AP3D1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.