Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF08210 APOBEC-like N-terminal domain |
Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. |
Biological Process |
GO:0009615 response to virus GO:0010528 regulation of transposition GO:0010529 negative regulation of transposition GO:0032196 transposition GO:0051607 defense response to virus GO:0098542 defense response to other organism |
Molecular Function |
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0019239 deaminase activity GO:0047844 deoxycytidine deaminase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-75094: Formation of the Editosome R-HSA-74160: Gene Expression R-HSA-75072: mRNA Editing R-HSA-72200: mRNA Editing |
Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between APOBEC3B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between APOBEC3B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of APOBEC3B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of APOBEC3B in various data sets.
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Points in the above scatter plot represent the mutation difference of APOBEC3B in various data sets.
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Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of APOBEC3B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of APOBEC3B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by APOBEC3B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of APOBEC3B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of APOBEC3B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between APOBEC3B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | APOBEC3B |
Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
Aliases | PHRBNL; FLJ21201; phorbolin 3; ARCD3; DJ742C19.2; bK150C2.2; apolipoprotein B mRNA editing enzyme catalytic ...... |
Chromosomal Location | 22q13.1-q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting APOBEC3B collected from DrugBank database. |
There is no record. |