Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL). |
Domain |
PF11032 ApoM domain |
Function |
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. |
Biological Process |
GO:0001523 retinoid metabolic process GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0006869 lipid transport GO:0009636 response to toxic substance GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0010876 lipid localization GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0016101 diterpenoid metabolic process GO:0030301 cholesterol transport GO:0033344 cholesterol efflux GO:0034284 response to monosaccharide GO:0034367 macromolecular complex remodeling GO:0034368 protein-lipid complex remodeling GO:0034369 plasma lipoprotein particle remodeling GO:0034375 high-density lipoprotein particle remodeling GO:0034377 plasma lipoprotein particle assembly GO:0034380 high-density lipoprotein particle assembly GO:0034381 plasma lipoprotein particle clearance GO:0034384 high-density lipoprotein particle clearance GO:0034441 plasma lipoprotein particle oxidation GO:0034442 regulation of lipoprotein oxidation GO:0034443 negative regulation of lipoprotein oxidation GO:0034444 regulation of plasma lipoprotein particle oxidation GO:0034445 negative regulation of plasma lipoprotein particle oxidation GO:0042157 lipoprotein metabolic process GO:0042160 lipoprotein modification GO:0042161 lipoprotein oxidation GO:0042632 cholesterol homeostasis GO:0043691 reverse cholesterol transport GO:0050746 regulation of lipoprotein metabolic process GO:0050748 negative regulation of lipoprotein metabolic process GO:0055088 lipid homeostasis GO:0055092 sterol homeostasis GO:0065005 protein-lipid complex assembly GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0097006 regulation of plasma lipoprotein particle levels GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification |
Molecular Function |
GO:0005319 lipid transporter activity GO:0005543 phospholipid binding GO:0016209 antioxidant activity |
Cellular Component |
GO:0032994 protein-lipid complex GO:0034358 plasma lipoprotein particle GO:0034361 very-low-density lipoprotein particle GO:0034362 low-density lipoprotein particle GO:0034364 high-density lipoprotein particle GO:0034365 discoidal high-density lipoprotein particle GO:0034366 spherical high-density lipoprotein particle GO:0034385 triglyceride-rich lipoprotein particle GO:1990777 lipoprotein particle |
KEGG | - |
Reactome |
R-HSA-1430728: Metabolism R-HSA-6806667: Metabolism of fat-soluble vitamins R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-975634: Retinoid metabolism and transport R-HSA-162582: Signal Transduction R-HSA-2187338: Visual phototransduction |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between APOM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of APOM in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of APOM in various data sets.
|
There is no record. |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of APOM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of APOM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by APOM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of APOM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of APOM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | APOM |
Name | apolipoprotein M |
Aliases | G3a; NG20; HSPC336; apo-M; NG20-like protein; alternative name: G3a, NG20; protein G3a |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between APOM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |