Browse AQP3

Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney.
Domain PF00230 Major intrinsic protein
Function

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0003014 renal system process
GO:0003091 renal water homeostasis
GO:0003097 renal water transport
GO:0006833 water transport
GO:0006884 cell volume homeostasis
GO:0007584 response to nutrient
GO:0007588 excretion
GO:0008361 regulation of cell size
GO:0008544 epidermis development
GO:0008643 carbohydrate transport
GO:0009913 epidermal cell differentiation
GO:0009991 response to extracellular stimulus
GO:0009992 cellular water homeostasis
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0015791 polyol transport
GO:0015793 glycerol transport
GO:0015840 urea transport
GO:0015850 organic hydroxy compound transport
GO:0019755 one-carbon compound transport
GO:0030104 water homeostasis
GO:0030216 keratinocyte differentiation
GO:0030856 regulation of epithelial cell differentiation
GO:0031667 response to nutrient levels
GO:0032526 response to retinoic acid
GO:0032535 regulation of cellular component size
GO:0033273 response to vitamin
GO:0033280 response to vitamin D
GO:0042044 fluid transport
GO:0042476 odontogenesis
GO:0042886 amide transport
GO:0043588 skin development
GO:0045604 regulation of epidermal cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045682 regulation of epidermis development
GO:0048871 multicellular organismal homeostasis
GO:0050878 regulation of body fluid levels
GO:0050891 multicellular organismal water homeostasis
GO:0051592 response to calcium ion
GO:0070293 renal absorption
GO:0070295 renal water absorption
GO:0071918 urea transmembrane transport
GO:0090066 regulation of anatomical structure size
Molecular Function GO:0005372 water transmembrane transporter activity
GO:0015144 carbohydrate transmembrane transporter activity
GO:0015166 polyol transmembrane transporter activity
GO:0015168 glycerol transmembrane transporter activity
GO:0015204 urea transmembrane transporter activity
GO:0015250 water channel activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
GO:0015665 alcohol transmembrane transporter activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
GO:0042887 amide transmembrane transporter activity
GO:1901476 carbohydrate transporter activity
GO:1901618 organic hydroxy compound transmembrane transporter activity
Cellular Component GO:0016323 basolateral plasma membrane
> KEGG and Reactome Pathway
 
KEGG hsa04962 Vasopressin-regulated water reabsorption
Reactome R-HSA-445717: Aquaporin-mediated transport
R-HSA-432047: Passive transport by Aquaporins
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AQP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AQP3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AQP3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3990.635
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.4950.395
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.8010.144
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4010.611
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.290.905
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5260.843
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5660.502
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.060.411
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0220.987
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.320.815
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7370.723
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.870.00333
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AQP3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AQP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AQP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AQP3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AQP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AQP3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AQP3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAQP3
Nameaquaporin 3 (Gill blood group)
Aliases GIL; Gill blood group; aquaporin 3; aquaporin 3 (GIL blood group); AQP-3; aquaglyceroporin-3; Aquaporin-3
Chromosomal Location9p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AQP3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.