Browse AQP5

Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Apical cell membrane Multi-pass membrane protein
Domain PF00230 Major intrinsic protein
Function

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0006833 water transport
GO:0006884 cell volume homeostasis
GO:0007423 sensory organ development
GO:0007586 digestion
GO:0007588 excretion
GO:0007589 body fluid secretion
GO:0008361 regulation of cell size
GO:0008643 carbohydrate transport
GO:0009992 cellular water homeostasis
GO:0015669 gas transport
GO:0015670 carbon dioxide transport
GO:0015791 polyol transport
GO:0015793 glycerol transport
GO:0015850 organic hydroxy compound transport
GO:0019755 one-carbon compound transport
GO:0022600 digestive system process
GO:0030104 water homeostasis
GO:0030157 pancreatic juice secretion
GO:0032535 regulation of cellular component size
GO:0032941 secretion by tissue
GO:0042044 fluid transport
GO:0042476 odontogenesis
GO:0043010 camera-type eye development
GO:0046541 saliva secretion
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0050878 regulation of body fluid levels
GO:0090066 regulation of anatomical structure size
GO:0090596 sensory organ morphogenesis
Molecular Function GO:0005372 water transmembrane transporter activity
GO:0015144 carbohydrate transmembrane transporter activity
GO:0015166 polyol transmembrane transporter activity
GO:0015168 glycerol transmembrane transporter activity
GO:0015250 water channel activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
GO:0015665 alcohol transmembrane transporter activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
GO:1901476 carbohydrate transporter activity
GO:1901618 organic hydroxy compound transmembrane transporter activity
Cellular Component GO:0005902 microvillus
GO:0009925 basal plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0098858 actin-based cell projection
> KEGG and Reactome Pathway
 
KEGG hsa04970 Salivary secretion
Reactome R-HSA-445717: Aquaporin-mediated transport
R-HSA-432047: Passive transport by Aquaporins
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AQP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AQP5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AQP5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5670.311
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3470.705
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.2430.111
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.7310.0467
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.1330.38
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.4780.0873
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.7660.379
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.1620.441
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5090.735
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1410.648
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AQP5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AQP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AQP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AQP5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AQP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AQP5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AQP5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAQP5
Nameaquaporin 5
Aliases AQP-5; PPKB; Aquaporin-5
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AQP5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.