Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. |
Domain |
PF02166 Androgen receptor PF00104 Ligand-binding domain of nuclear hormone receptor PF00105 Zinc finger |
Function |
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. ; FUNCTION: Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. |
Biological Process |
GO:0001655 urogenital system development GO:0001701 in utero embryonic development GO:0001708 cell fate specification GO:0001759 organ induction GO:0001763 morphogenesis of a branching structure GO:0002064 epithelial cell development GO:0003002 regionalization GO:0003013 circulatory system process GO:0003073 regulation of systemic arterial blood pressure GO:0003156 regulation of animal organ formation GO:0003382 epithelial cell morphogenesis GO:0006352 DNA-templated transcription, initiation GO:0006359 regulation of transcription from RNA polymerase III promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006383 transcription from RNA polymerase III promoter GO:0007009 plasma membrane organization GO:0007283 spermatogenesis GO:0007338 single fertilization GO:0007389 pattern specification process GO:0007530 sex determination GO:0007548 sex differentiation GO:0007565 female pregnancy GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0008406 gonad development GO:0008584 male gonad development GO:0009566 fertilization GO:0009755 hormone-mediated signaling pathway GO:0010092 specification of animal organ identity GO:0010453 regulation of cell fate commitment GO:0016049 cell growth GO:0016331 morphogenesis of embryonic epithelium GO:0018993 somatic sex determination GO:0019102 male somatic sex determination GO:0022612 gland morphogenesis GO:0030238 male sex determination GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030539 male genitalia development GO:0030850 prostate gland development GO:0030879 mammary gland development GO:0031128 developmental induction GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway GO:0033327 Leydig cell differentiation GO:0035112 genitalia morphogenesis GO:0035239 tube morphogenesis GO:0035264 multicellular organism growth GO:0035265 organ growth GO:0040019 positive regulation of embryonic development GO:0042659 regulation of cell fate specification GO:0043401 steroid hormone mediated signaling pathway GO:0043410 positive regulation of MAPK cascade GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway GO:0044706 multi-multicellular organism process GO:0045112 integrin biosynthetic process GO:0045113 regulation of integrin biosynthetic process GO:0045137 development of primary sexual characteristics GO:0045165 cell fate commitment GO:0045720 negative regulation of integrin biosynthetic process GO:0045726 positive regulation of integrin biosynthetic process GO:0045945 positive regulation of transcription from RNA polymerase III promoter GO:0045995 regulation of embryonic development GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048009 insulin-like growth factor receptor signaling pathway GO:0048232 male gamete generation GO:0048545 response to steroid hormone GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048645 animal organ formation GO:0048732 gland development GO:0048754 branching morphogenesis of an epithelial tube GO:0048806 genitalia development GO:0048808 male genitalia morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051259 protein oligomerization GO:0060135 maternal process involved in female pregnancy GO:0060443 mammary gland morphogenesis GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060512 prostate gland morphogenesis GO:0060513 prostatic bud formation GO:0060514 prostate induction GO:0060515 prostate field specification GO:0060520 activation of prostate induction by androgen receptor signaling pathway GO:0060562 epithelial tube morphogenesis GO:0060571 morphogenesis of an epithelial fold GO:0060572 morphogenesis of an epithelial bud GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis GO:0060601 lateral sprouting from an epithelium GO:0060603 mammary gland duct morphogenesis GO:0060685 regulation of prostatic bud formation GO:0060688 regulation of morphogenesis of a branching structure GO:0060736 prostate gland growth GO:0060740 prostate gland epithelium morphogenesis GO:0060742 epithelial cell differentiation involved in prostate gland development GO:0060745 mammary gland branching involved in pregnancy GO:0060748 tertiary branching involved in mammary gland duct morphogenesis GO:0060749 mammary gland alveolus development GO:0061138 morphogenesis of a branching epithelium GO:0061180 mammary gland epithelium development GO:0061377 mammary gland lobule development GO:0061458 reproductive system development GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072520 seminiferous tubule development GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090003 regulation of establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090598 male anatomical structure morphogenesis GO:0097191 extrinsic apoptotic signaling pathway GO:1903076 regulation of protein localization to plasma membrane GO:1903729 regulation of plasma membrane organization GO:1904375 regulation of protein localization to cell periphery GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:1990778 protein localization to cell periphery GO:2000027 regulation of organ morphogenesis GO:2000241 regulation of reproductive process GO:2000243 positive regulation of reproductive process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003707 steroid hormone receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004882 androgen receptor activity GO:0005496 steroid binding GO:0005497 androgen binding GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0042562 hormone binding GO:0051117 ATPase binding GO:0070974 POU domain binding GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part |
KEGG |
hsa04114 Oocyte meiosis |
Reactome |
R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5688426: Deubiquitination R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-392499: Metabolism of proteins R-HSA-383280: Nuclear Receptor transcription pathway R-HSA-597592: Post-translational protein modification R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-5689880: Ub-specific processing proteases |
Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between AR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AR in various data sets.
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Points in the above scatter plot represent the mutation difference of AR in various data sets.
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Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | AR |
Name | androgen receptor |
Aliases | NR3C4; SMAX1; HUMARA; testicular feminization; Kennedy disease; DHTR; SBMA; dihydrotestosterone receptor; sp ...... |
Chromosomal Location | Xq12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AR collected from DrugBank database. |
Details on drugs targeting AR.
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