Summary | |
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Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF01412 Putative GTPase activating protein for Arf PF00169 PH domain PF00788 Ras association (RalGDS/AF-6) domain PF00620 RhoGAP domain PF00536 SAM domain (Sterile alpha motif) |
Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). |
Biological Process |
GO:0051056 regulation of small GTPase mediated signal transduction |
Molecular Function |
GO:0005096 GTPase activator activity GO:0005543 phospholipid binding GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding GO:0008047 enzyme activator activity GO:0030695 GTPase regulator activity GO:0035091 phosphatidylinositol binding GO:0060589 nucleoside-triphosphatase regulator activity GO:1901981 phosphatidylinositol phosphate binding |
Cellular Component | - |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARAP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARAP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARAP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ARAP2 in various data sets.
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Summary | |
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Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARAP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARAP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARAP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARAP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARAP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARAP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ARAP2 |
Name | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | PARX; CENTD1; centaurin, delta 1; Arf and Rho GAP adapter protein 2; centaurin-delta-1; cnt-d1; Protein PARX ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ARAP2 collected from DrugBank database. |
There is no record. |