Summary | |
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Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus Cytoplasm, perinuclear region |
Domain |
PF00025 ADP-ribosylation factor family |
Function |
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. |
Biological Process |
GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0008654 phospholipid biosynthetic process GO:0045017 glycerolipid biosynthetic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0048193 Golgi vesicle transport |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component | - |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6807878: COPI-mediated anterograde transport R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-1483255: PI Metabolism R-HSA-1483257: Phospholipid metabolism R-HSA-597592: Post-translational protein modification R-HSA-1660514: Synthesis of PIPs at the Golgi membrane R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARF3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARF3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ARF3 in various data sets.
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Summary | |
---|---|
Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARF3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARF3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ARF3 |
Name | ADP-ribosylation factor 3 |
Aliases | |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARF3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |