Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF00491 Arginase family |
Function |
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189). |
Biological Process |
GO:0000050 urea cycle GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001822 kidney development GO:0001823 mesonephros development GO:0003012 muscle system process GO:0006520 cellular amino acid metabolic process GO:0006525 arginine metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0009064 glutamine family amino acid metabolic process GO:0019627 urea metabolic process GO:0046209 nitric oxide metabolic process GO:0071941 nitrogen cycle metabolic process GO:0072001 renal system development GO:0072073 kidney epithelium development GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072593 reactive oxygen species metabolic process GO:1901605 alpha-amino acid metabolic process GO:1903409 reactive oxygen species biosynthetic process GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0004053 arginase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00330 Arginine and proline metabolism hsa01100 Metabolic pathways hsa01230 Biosynthesis of amino acids |
Reactome |
R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-351202: Metabolism of polyamines R-HSA-70635: Urea cycle |
Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ARG2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARG2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARG2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ARG2 in various data sets.
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Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARG2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ARG2 |
Name | arginase 2 |
Aliases | arginase, type II; L-arginine amidinohydrolase; L-arginine ureahydrolase; kidney arginase; kidney-type argin ...... |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ARG2 collected from DrugBank database. |
Details on drugs targeting ARG2.
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