Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). |
Domain |
PF00169 PH domain PF00620 RhoGAP domain |
Function |
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). |
Biological Process |
GO:0001525 angiogenesis GO:0048514 blood vessel morphogenesis GO:0051056 regulation of small GTPase mediated signal transduction |
Molecular Function |
GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0030695 GTPase regulator activity GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG | - |
Reactome |
R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARHGAP22 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARHGAP22 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARHGAP22 in various data sets.
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Points in the above scatter plot represent the mutation difference of ARHGAP22 in various data sets.
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Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARHGAP22. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARHGAP22. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARHGAP22. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARHGAP22. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARHGAP22 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARHGAP22 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ARHGAP22 |
Name | Rho GTPase activating protein 22 |
Aliases | RhoGap22; rho-type GTPase-activating protein 22; Rho GTPase-activating protein 22 |
Chromosomal Location | 10q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ARHGAP22 collected from DrugBank database. |
There is no record. |