Summary | |
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Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane Peripheral membrane protein Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. |
Domain |
PF01846 FF domain PF00071 Ras family PF00620 RhoGAP domain PF16512 p190-A and -B Rho GAPs FF domain |
Function |
GTPase-activating protein for Rho family members (PubMed:8537347). |
Biological Process |
GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0030879 mammary gland development GO:0048732 gland development GO:0051056 regulation of small GTPase mediated signal transduction |
Molecular Function |
GO:0003924 GTPase activity GO:0005096 GTPase activator activity GO:0005525 GTP binding GO:0008047 enzyme activator activity GO:0019001 guanyl nucleotide binding GO:0030695 GTPase regulator activity GO:0032561 guanyl ribonucleotide binding GO:0042169 SH2 domain binding GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component | - |
KEGG |
hsa04510 Focal adhesion hsa04670 Leukocyte transendothelial migration |
Reactome |
R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARHGAP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARHGAP5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARHGAP5 in various data sets.
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Points in the above scatter plot represent the mutation difference of ARHGAP5 in various data sets.
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Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARHGAP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARHGAP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARHGAP5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARHGAP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARHGAP5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARHGAP5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ARHGAP5 |
Name | Rho GTPase activating protein 5 |
Aliases | RhoGAP5; p190-B; p190BRhoGAP; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 R ...... |
Chromosomal Location | 14q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ARHGAP5 collected from DrugBank database. |
There is no record. |