Browse ARHGEF25

Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Cytoplasm, myofibril, sarcomere Note=Highly colocalizes with actin regions.
Domain PF00621 RhoGEF domain
Function

May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).

> Gene Ontology
 
Biological Process GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0046578 regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Cellular Component GO:0030016 myofibril
GO:0030017 sarcomere
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ARHGEF25 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ARHGEF25 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ARHGEF25 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.9740.033
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2370.405
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7760.466
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5760.322
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4270.844
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.7610.787
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2140.571
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.370.766
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0780.949
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.120.932
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5180.789
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2350.131
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ARHGEF25 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.93.74.20.636
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.67.75.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARHGEF25. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARHGEF25. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARHGEF25.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARHGEF25. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ARHGEF25 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ARHGEF25 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolARHGEF25
NameRho guanine nucleotide exchange factor (GEF) 25
Aliases GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ARHGEF25 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.