Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Cytoplasm, myofibril, sarcomere Note=Highly colocalizes with actin regions. |
Domain |
PF00621 RhoGEF domain |
Function |
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). |
Biological Process |
GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0035023 regulation of Rho protein signal transduction GO:0046578 regulation of Ras protein signal transduction GO:0051056 regulation of small GTPase mediated signal transduction |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005089 Rho guanyl-nucleotide exchange factor activity |
Cellular Component |
GO:0030016 myofibril GO:0030017 sarcomere GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome |
R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARHGEF25 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARHGEF25 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARHGEF25 in various data sets.
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Points in the above scatter plot represent the mutation difference of ARHGEF25 in various data sets.
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Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARHGEF25. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARHGEF25. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARHGEF25. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARHGEF25. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARHGEF25 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARHGEF25 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ARHGEF25 |
Name | Rho guanine nucleotide exchange factor (GEF) 25 |
Aliases | GEFT; p63RhoGEF; RAC/CDC42 exchange factor; RhoA/RAC/CDC42 exchange factor; guanine nucleotide exchange fact ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ARHGEF25 collected from DrugBank database. |
There is no record. |