Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF01388 ARID/BRIGHT DNA binding domain PF12031 SWI/SNF-like complex subunit BAF250/Osa |
Function |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
Biological Process |
GO:0001654 eye development GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001890 placenta development GO:0002072 optic cup morphogenesis involved in camera-type eye development GO:0003205 cardiac chamber development GO:0003408 optic cup formation involved in camera-type eye development GO:0006333 chromatin assembly or disassembly GO:0006337 nucleosome disassembly GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006344 maintenance of chromatin silencing GO:0007423 sensory organ development GO:0007507 heart development GO:0009755 hormone-mediated signaling pathway GO:0014020 primary neural tube formation GO:0014706 striated muscle tissue development GO:0016331 morphogenesis of embryonic epithelium GO:0016458 gene silencing GO:0021915 neural tube development GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030900 forebrain development GO:0031076 embryonic camera-type eye development GO:0031498 chromatin disassembly GO:0031958 corticosteroid receptor signaling pathway GO:0032984 macromolecular complex disassembly GO:0032986 protein-DNA complex disassembly GO:0034728 nucleosome organization GO:0035051 cardiocyte differentiation GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0040029 regulation of gene expression, epigenetic GO:0042692 muscle cell differentiation GO:0042766 nucleosome mobilization GO:0042921 glucocorticoid receptor signaling pathway GO:0043010 camera-type eye development GO:0043044 ATP-dependent chromatin remodeling GO:0043241 protein complex disassembly GO:0043401 steroid hormone mediated signaling pathway GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0048048 embryonic eye morphogenesis GO:0048096 chromatin-mediated maintenance of transcription GO:0048545 response to steroid hormone GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0048608 reproductive structure development GO:0048738 cardiac muscle tissue development GO:0051146 striated muscle cell differentiation GO:0055007 cardiac muscle cell differentiation GO:0060537 muscle tissue development GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060674 placenta blood vessel development GO:0060900 embryonic camera-type eye formation GO:0061458 reproductive system development GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071824 protein-DNA complex subunit organization GO:0072175 epithelial tube formation GO:0090596 sensory organ morphogenesis GO:1901998 toxin transport |
Molecular Function |
GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0016922 ligand-dependent nuclear receptor binding GO:0031491 nucleosome binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016514 SWI/SNF complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0071564 npBAF complex GO:0071565 nBAF complex GO:0090544 BAF-type complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214858: RMTs methylate histone arginines |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARID1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARID1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARID1A in various data sets.
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Points in the above scatter plot represent the mutation difference of ARID1A in various data sets.
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Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARID1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARID1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARID1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARID1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARID1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARID1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ARID1A |
Name | AT rich interactive domain 1A (SWI-like) |
Aliases | B120; C10rf4; BAF250; BAF250a; C1orf4; SMARCF1; SWI/SNF related, matrix associated, actin dependent regulato ...... |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ARID1A collected from DrugBank database. |
There is no record. |