Browse ARID2

Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF01388 ARID/BRIGHT DNA binding domain
PF02257 RFX DNA-binding domain
Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.

> Gene Ontology
 
Biological Process GO:0006333 chromatin assembly or disassembly
GO:0006337 nucleosome disassembly
GO:0030336 negative regulation of cell migration
GO:0031498 chromatin disassembly
GO:0032984 macromolecular complex disassembly
GO:0032986 protein-DNA complex disassembly
GO:0034728 nucleosome organization
GO:0040013 negative regulation of locomotion
GO:0043241 protein complex disassembly
GO:0051271 negative regulation of cellular component movement
GO:0071824 protein-DNA complex subunit organization
GO:2000146 negative regulation of cell motility
Molecular Function -
Cellular Component GO:0070603 SWI/SNF superfamily-type complex
GO:0090544 BAF-type complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214858: RMTs methylate histone arginines
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ARID2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ARID2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -3.06; FDR: 0.00979 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.59 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ARID2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0880.743
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0440.964
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1240.878
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0360.919
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2560.916
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2410.938
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1420.669
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1550.919
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1530.926
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5540.519
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.990.421
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0030.964
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ARID2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.98.217.70.0389
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.910.215.70.101
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21171911.87.20.672
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.418.2-2.81
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARID2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARID2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARID2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARID2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ARID2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ARID2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolARID2
NameAT rich interactive domain 2 (ARID, RFX-like)
Aliases KIAA1557; DKFZp686G052; FLJ30619; BAF200; ARID domain-containing protein 2; BRG1-associated factor 200; zinc ......
Chromosomal Location12q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ARID2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.