Browse ARIH1

Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Nucleus, Cajal body Note=Mainly cytoplasmic (PubMed:11278816). Present in Lewy body (PubMed:21590270).
Domain PF01485 IBR domain
Function

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).

> Gene Ontology
 
Biological Process GO:0000209 protein polyubiquitination
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010498 proteasomal protein catabolic process
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042176 regulation of protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0061136 regulation of proteasomal protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
Molecular Function GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0061630 ubiquitin protein ligase activity
GO:0061659 ubiquitin-like protein ligase activity
Cellular Component GO:0000151 ubiquitin ligase complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1169410: Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1169408: ISG15 antiviral mechanism
R-HSA-168256: Immune System
R-HSA-913531: Interferon Signaling
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ARIH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ARIH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.72 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ARIH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2490.3
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5750.753
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.010.994
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5560.0529
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6650.752
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4220.87
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0890.826
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0250.989
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2010.919
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3270.776
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6510.704
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0020.971
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ARIH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARIH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARIH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARIH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARIH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ARIH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ARIH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolARIH1
Nameariadne RBR E3 ubiquitin protein ligase 1
Aliases HARI; HHARI; UBCH7BP; ARI; ariadne, Drosophila, homolog of; ariadne (Drosophila) homolog, ubiquitin-conjugat ......
Chromosomal Location15q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ARIH1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.