Summary | |
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Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus, Golgi stack. |
Domain |
PF00884 Sulfatase |
Function |
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. |
Biological Process |
GO:0001501 skeletal system development GO:0006643 membrane lipid metabolic process GO:0006664 glycolipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006687 glycosphingolipid metabolic process GO:0043687 post-translational protein modification GO:1903509 liposaccharide metabolic process |
Molecular Function |
GO:0004065 arylsulfatase activity GO:0008484 sulfuric ester hydrolase activity |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005795 Golgi stack GO:0031984 organelle subcompartment GO:0098791 Golgi subcompartment |
KEGG | - |
Reactome |
R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-1660662: Glycosphingolipid metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-428157: Sphingolipid metabolism R-HSA-1663150: The activation of arylsulfatases |
Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ARSE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ARSE in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ARSE in various data sets.
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Points in the above scatter plot represent the mutation difference of ARSE in various data sets.
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Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ARSE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ARSE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ARSE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ARSE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ARSE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ARSE |
Name | arylsulfatase E (chondrodysplasia punctata 1) |
Aliases | CDPX; CDPX1; ASE; CDPXR; Arylsulfatase E |
Chromosomal Location | Xp22.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ARSE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |