Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF12796 Ankyrin repeats (3 copies) PF07525 SOCS box |
Function |
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). |
Biological Process |
GO:0001570 vasculogenesis GO:0048514 blood vessel morphogenesis GO:0051865 protein autoubiquitination GO:1901342 regulation of vasculature development GO:1904018 positive regulation of vasculature development GO:2001212 regulation of vasculogenesis GO:2001214 positive regulation of vasculogenesis |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0031461 cullin-RING ubiquitin ligase complex GO:0031462 Cul2-RING ubiquitin ligase complex GO:0031466 Cul5-RING ubiquitin ligase complex |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System |
Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ASB4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ASB4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ASB4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ASB4 in various data sets.
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Points in the above scatter plot represent the mutation difference of ASB4 in various data sets.
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Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ASB4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ASB4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ASB4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ASB4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ASB4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ASB4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ASB4 |
Name | ankyrin repeat and SOCS box containing 4 |
Aliases | ASB-4; ankyrin repeat and SOCS box-containing 4; Ankyrin repeat and SOCS box protein 4 |
Chromosomal Location | 7q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ASB4 collected from DrugBank database. |
There is no record. |