Browse ASMT

Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF16864 Dimerisation domain
PF00891 O-methyltransferase
Function

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.

> Gene Ontology
 
Biological Process GO:0006576 cellular biogenic amine metabolic process
GO:0006586 indolalkylamine metabolic process
GO:0009308 amine metabolic process
GO:0009309 amine biosynthetic process
GO:0010817 regulation of hormone levels
GO:0030186 melatonin metabolic process
GO:0030187 melatonin biosynthetic process
GO:0032259 methylation
GO:0034754 cellular hormone metabolic process
GO:0042401 cellular biogenic amine biosynthetic process
GO:0042430 indole-containing compound metabolic process
GO:0042435 indole-containing compound biosynthetic process
GO:0042445 hormone metabolic process
GO:0042446 hormone biosynthetic process
GO:0044106 cellular amine metabolic process
GO:0046219 indolalkylamine biosynthetic process
Molecular Function GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0017096 acetylserotonin O-methyltransferase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00380 Tryptophan metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-209776: Amine-derived hormones
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-209931: Serotonin and melatonin biosynthesis
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ASMT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ASMT in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ASMT in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.3090.0182
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0430.278
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.6450.129
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0960.642
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ASMT in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ASMT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ASMT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ASMT.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ASMT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ASMT expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ASMT and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolASMT
Nameacetylserotonin O-methyltransferase
Aliases HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ......
Chromosomal LocationXp22.3 and Yp11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ASMT collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ASMT.
ID Name Drug Type Targets #Targets
DB01065MelatoninSmall MoleculeASMT, CALR, EPX, ESR1, MPO, MTNR1A, MTNR1B, NQO2, RORB9