Summary | |
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Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF16864 Dimerisation domain PF00891 O-methyltransferase |
Function |
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. |
Biological Process |
GO:0006576 cellular biogenic amine metabolic process GO:0006586 indolalkylamine metabolic process GO:0009308 amine metabolic process GO:0009309 amine biosynthetic process GO:0010817 regulation of hormone levels GO:0030186 melatonin metabolic process GO:0030187 melatonin biosynthetic process GO:0032259 methylation GO:0034754 cellular hormone metabolic process GO:0042401 cellular biogenic amine biosynthetic process GO:0042430 indole-containing compound metabolic process GO:0042435 indole-containing compound biosynthetic process GO:0042445 hormone metabolic process GO:0042446 hormone biosynthetic process GO:0044106 cellular amine metabolic process GO:0046219 indolalkylamine biosynthetic process |
Molecular Function |
GO:0008168 methyltransferase activity GO:0008171 O-methyltransferase activity GO:0008172 S-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0017096 acetylserotonin O-methyltransferase activity |
Cellular Component | - |
KEGG |
hsa00380 Tryptophan metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-209776: Amine-derived hormones R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-209931: Serotonin and melatonin biosynthesis |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ASMT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ASMT in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ASMT in various data sets.
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Points in the above scatter plot represent the mutation difference of ASMT in various data sets.
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Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ASMT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ASMT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ASMT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ASMT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ASMT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ASMT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ASMT |
Name | acetylserotonin O-methyltransferase |
Aliases | HIOMT; ASMTY; HIOMTY; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); ...... |
Chromosomal Location | Xp22.3 and Yp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ASMT collected from DrugBank database. |
Details on drugs targeting ASMT.
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