Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00004 ATPase family associated with various cellular activities (AAA) PF00439 Bromodomain |
Function |
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. |
Biological Process |
GO:0006342 chromatin silencing GO:0016458 gene silencing GO:0031935 regulation of chromatin silencing GO:0031936 negative regulation of chromatin silencing GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization |
Molecular Function |
GO:0003682 chromatin binding GO:0016887 ATPase activity GO:0042393 histone binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATAD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATAD2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATAD2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ATAD2 in various data sets.
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Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATAD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATAD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATAD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATAD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATAD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATAD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATAD2 |
Name | ATPase family, AAA domain containing 2 |
Aliases | PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ...... |
Chromosomal Location | 8q24.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATAD2 collected from DrugBank database. |
There is no record. |