Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling. |
Domain |
PF00170 bZIP transcription factor |
Function |
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. |
Biological Process |
GO:0001654 eye development GO:0006457 protein folding GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0007423 sensory organ development GO:0007601 visual perception GO:0030968 endoplasmic reticulum unfolded protein response GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036500 ATF6-mediated unfolded protein response GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0050953 sensory perception of light stimulus GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
Molecular Function |
GO:0003713 transcription coactivator activity GO:0031625 ubiquitin protein ligase binding GO:0035497 cAMP response element binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-380994: ATF4 activates genes R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones R-HSA-392499: Metabolism of proteins R-HSA-381042: PERK regulates gene expression R-HSA-381119: Unfolded Protein Response (UPR) |
Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATF6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ATF6 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATF6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATF6 in various data sets.
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Points in the above scatter plot represent the mutation difference of ATF6 in various data sets.
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Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATF6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATF6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATF6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATF6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATF6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATF6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATF6 |
Name | activating transcription factor 6 |
Aliases | ATF6A; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; ...... |
Chromosomal Location | 1q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATF6 collected from DrugBank database. |
Details on drugs targeting ATF6.
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