Summary | |
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Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol Preautophagosomal structure Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. |
Domain |
PF10033 Autophagy-related protein 13 |
Function |
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. |
Biological Process |
GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0000423 macromitophagy GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0006914 autophagy GO:0007033 vacuole organization GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016236 macroautophagy GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0051222 positive regulation of protein transport GO:0061726 mitochondrion disassembly GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:0098779 mitophagy in response to mitochondrial depolarization GO:0098780 response to mitochondrial depolarisation GO:1903008 organelle disassembly GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization GO:1905037 autophagosome organization |
Molecular Function | - |
Cellular Component |
GO:0000407 pre-autophagosomal structure GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex GO:1990316 ATG1/ULK1 kinase complex |
KEGG |
hsa04140 Regulation of autophagy |
Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-1632852: Macroautophagy |
Summary | |
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Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATG13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATG13 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATG13 in various data sets.
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Points in the above scatter plot represent the mutation difference of ATG13 in various data sets.
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Summary | |
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Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG13. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATG13 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATG13 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ATG13 |
Name | autophagy related 13 |
Aliases | KIAA0652; ATG13 autophagy related 13 homolog (S. cerevisiae); PARATARG8; ATG13 autophagy related 13 homolog; ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATG13 collected from DrugBank database. |
There is no record. |