Browse ATG2A

Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.
Domain PF13329 Autophagy-related protein 2 CAD motif
PF09333 Autophagy-related protein C terminal domain
PF12624 N-terminal region of Chorein or VPS13
Function

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000422 mitophagy
GO:0006914 autophagy
GO:0007033 vacuole organization
GO:0016236 macroautophagy
GO:0044804 nucleophagy
GO:0061726 mitochondrion disassembly
GO:1903008 organelle disassembly
GO:1905037 autophagosome organization
Molecular Function -
Cellular Component GO:0000407 pre-autophagosomal structure
GO:0005811 lipid particle
GO:0019898 extrinsic component of membrane
GO:0034045 pre-autophagosomal structure membrane
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
Reactome -
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATG2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATG2A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATG2A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7150.00238
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7720.561
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.6730.498
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1410.715
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1770.941
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5480.863
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.290.388
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6010.634
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.10.946
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2030.83
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6210.629
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0270.667
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATG2A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 594011.128.90.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG2A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATG2A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATG2A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATG2A
Nameautophagy related 2A
Aliases KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ......
Chromosomal Location11q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATG2A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.