Summary | |
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Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. |
Domain |
PF13329 Autophagy-related protein 2 CAD motif PF09333 Autophagy-related protein C terminal domain PF12624 N-terminal region of Chorein or VPS13 |
Function |
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. |
Biological Process |
GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0006914 autophagy GO:0007033 vacuole organization GO:0016236 macroautophagy GO:0044804 nucleophagy GO:0061726 mitochondrion disassembly GO:1903008 organelle disassembly GO:1905037 autophagosome organization |
Molecular Function | - |
Cellular Component |
GO:0000407 pre-autophagosomal structure GO:0005811 lipid particle GO:0019898 extrinsic component of membrane GO:0034045 pre-autophagosomal structure membrane |
KEGG |
hsa04140 Regulation of autophagy |
Reactome | - |
Summary | |
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Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATG2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATG2A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATG2A in various data sets.
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Points in the above scatter plot represent the mutation difference of ATG2A in various data sets.
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Summary | |
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Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG2A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATG2A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATG2A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ATG2A |
Name | autophagy related 2A |
Aliases | KIAA0404; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2 autophagy related 2 homolog A; Autophagy- ...... |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATG2A collected from DrugBank database. |
There is no record. |