Browse ATG3

Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF03987 Autophagocytosis associated protein
PF10381 Autophagocytosis associated protein C-terminal
PF03986 Autophagocytosis associated protein (Atg3)
Function

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000422 mitophagy
GO:0006612 protein targeting to membrane
GO:0006909 phagocytosis
GO:0006914 autophagy
GO:0007033 vacuole organization
GO:0008637 apoptotic mitochondrial changes
GO:0010927 cellular component assembly involved in morphogenesis
GO:0016236 macroautophagy
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0030100 regulation of endocytosis
GO:0042384 cilium assembly
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0044782 cilium organization
GO:0044804 nucleophagy
GO:0045806 negative regulation of endocytosis
GO:0050764 regulation of phagocytosis
GO:0050765 negative regulation of phagocytosis
GO:0051051 negative regulation of transport
GO:0060271 cilium morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0060627 regulation of vesicle-mediated transport
GO:0061726 mitochondrion disassembly
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:1902017 regulation of cilium assembly
GO:1902115 regulation of organelle assembly
GO:1903008 organelle disassembly
GO:1905037 autophagosome organization
Molecular Function GO:0016874 ligase activity
GO:0019776 Atg8 ligase activity
GO:0019777 Atg12 transferase activity
GO:0019787 ubiquitin-like protein transferase activity
Cellular Component GO:0000151 ubiquitin ligase complex
GO:0000153 cytoplasmic ubiquitin ligase complex
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-1632852: Macroautophagy
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATG3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATG3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -0.85; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATG3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0920.628
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.120.962
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0710.969
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1770.524
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2410.877
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0950.962
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1020.804
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0070.997
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1870.92
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1920.911
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.210.938
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0960.115
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATG3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATG3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATG3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATG3
Nameautophagy related 3
Aliases PC3-96; FLJ22125; MGC15201; DKFZp564M1178; APG3L; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy rela ......
Chromosomal Location3q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATG3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.