Summary | |
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Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. |
Domain |
PF04106 Autophagy protein Apg5 |
Function |
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. ; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. ; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). |
Biological Process |
GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0006497 protein lipidation GO:0006501 C-terminal protein lipidation GO:0006914 autophagy GO:0006995 cellular response to nitrogen starvation GO:0007033 vacuole organization GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0010927 cellular component assembly involved in morphogenesis GO:0016236 macroautophagy GO:0018410 C-terminal protein amino acid modification GO:0022604 regulation of cell morphogenesis GO:0030031 cell projection assembly GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0035973 aggrephagy GO:0042157 lipoprotein metabolic process GO:0042158 lipoprotein biosynthetic process GO:0042384 cilium assembly GO:0042594 response to starvation GO:0043562 cellular response to nitrogen levels GO:0043687 post-translational protein modification GO:0044782 cilium organization GO:0044804 nucleophagy GO:0060271 cilium morphogenesis GO:0060491 regulation of cell projection assembly GO:0061726 mitochondrion disassembly GO:0071496 cellular response to external stimulus GO:1902017 regulation of cilium assembly GO:1902115 regulation of organelle assembly GO:1903008 organelle disassembly GO:1905037 autophagosome organization |
Molecular Function |
GO:0019776 Atg8 ligase activity |
Cellular Component |
GO:0000407 pre-autophagosomal structure GO:0005776 autophagosome GO:0005929 cilium GO:0005930 axoneme GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030670 phagocytic vesicle membrane GO:0034045 pre-autophagosomal structure membrane GO:0034274 Atg12-Atg5-Atg16 complex GO:0044441 ciliary part GO:0045335 phagocytic vesicle GO:0097014 ciliary plasm |
KEGG |
hsa04140 Regulation of autophagy hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway |
Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1632852: Macroautophagy R-HSA-5205647: Mitophagy R-HSA-936440: Negative regulators of RIG-I/MDA5 signaling R-HSA-5205685: Pink/Parkin Mediated Mitophagy R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
Summary | |
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Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATG5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATG5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATG5 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATG5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATG5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATG5 |
Name | autophagy related 5 |
Aliases | APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ...... |
Chromosomal Location | 6q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATG5 collected from DrugBank database. |
There is no record. |