Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00689 Cation transporting ATPase PF00690 Cation transporter/ATPase |
Function |
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. |
Biological Process |
GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0006813 potassium ion transport GO:0006814 sodium ion transport GO:0006818 hydrogen transport GO:0006875 cellular metal ion homeostasis GO:0006883 cellular sodium ion homeostasis GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0007215 glutamate receptor signaling pathway GO:0007611 learning or memory GO:0007612 learning GO:0007613 memory GO:0007626 locomotory behavior GO:0007632 visual behavior GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008306 associative learning GO:0008344 adult locomotory behavior GO:0008542 visual learning GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0010107 potassium ion import GO:0010248 establishment or maintenance of transmembrane electrochemical gradient GO:0010644 cell communication by electrical coupling GO:0015672 monovalent inorganic cation transport GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient GO:0015991 ATP hydrolysis coupled proton transport GO:0015992 proton transport GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030007 cellular potassium ion homeostasis GO:0030534 adult behavior GO:0035235 ionotropic glutamate receptor signaling pathway GO:0035637 multicellular organismal signaling GO:0035725 sodium ion transmembrane transport GO:0036376 sodium ion export from cell GO:0042391 regulation of membrane potential GO:0042493 response to drug GO:0044057 regulation of system process GO:0044708 single-organism behavior GO:0048545 response to steroid hormone GO:0050890 cognition GO:0055067 monovalent inorganic cation homeostasis GO:0055075 potassium ion homeostasis GO:0055078 sodium ion homeostasis GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0061337 cardiac conduction GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071436 sodium ion export GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0086036 regulation of cardiac muscle cell membrane potential GO:0086064 cell communication by electrical coupling involved in cardiac conduction GO:0086065 cell communication involved in cardiac conduction GO:0090662 ATP hydrolysis coupled transmembrane transport GO:1902600 hydrogen ion transmembrane transport GO:1903416 response to glycoside GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0001948 glycoprotein binding GO:0005391 sodium:potassium-exchanging ATPase activity GO:0005496 steroid binding GO:0008556 potassium-transporting ATPase activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0019829 cation-transporting ATPase activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0031748 D1 dopamine receptor binding GO:0042562 hormone binding GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043394 proteoglycan binding GO:0043395 heparan sulfate proteoglycan binding GO:0043492 ATPase activity, coupled to movement of substances GO:0046873 metal ion transmembrane transporter activity GO:0050780 dopamine receptor binding GO:0051087 chaperone binding GO:0086037 sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential GO:1901681 sulfur compound binding GO:1990239 steroid hormone binding |
Cellular Component |
GO:0005890 sodium:potassium-exchanging ATPase complex GO:0030424 axon GO:0030425 dendrite GO:0042383 sarcolemma GO:0043197 dendritic spine GO:0043209 myelin sheath GO:0044309 neuron spine GO:0044326 dendritic spine neck GO:0044327 dendritic spine head GO:0090533 cation-transporting ATPase complex GO:0098533 ATPase dependent transmembrane transport complex GO:0098794 postsynapse GO:1902495 transmembrane transporter complex GO:1904949 ATPase complex GO:1990351 transporter complex |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04260 Cardiac muscle contraction hsa04261 Adrenergic signaling in cardiomyocytes hsa04911 Insulin secretion hsa04918 Thyroid hormone synthesis hsa04919 Thyroid hormone signaling pathway hsa04960 Aldosterone-regulated sodium reabsorption hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04964 Proximal tubule bicarbonate reclamation hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion hsa04973 Carbohydrate digestion and absorption hsa04974 Protein digestion and absorption hsa04976 Bile secretion hsa04978 Mineral absorption |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-983712: Ion channel transport R-HSA-5578775: Ion homeostasis R-HSA-936837: Ion transport by P-type ATPases R-HSA-397014: Muscle contraction R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATP1A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATP1A3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATP1A3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ATP1A3 in various data sets.
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Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP1A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP1A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP1A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP1A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATP1A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATP1A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATP1A3 |
Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; sodium-potassium ATPase c ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATP1A3 collected from DrugBank database. |
Details on drugs targeting ATP1A3.
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