Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type II membrane protein Cell membrane, sarcolemma Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. |
Domain |
PF00287 Sodium / potassium ATPase beta chain |
Function |
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. ; FUNCTION: Involved in cell adhesion and establishing epithelial cell polarity. |
Biological Process |
GO:0001508 action potential GO:0001666 response to hypoxia GO:0002028 regulation of sodium ion transport GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0006813 potassium ion transport GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006883 cellular sodium ion homeostasis GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006941 striated muscle contraction GO:0006942 regulation of striated muscle contraction GO:0007009 plasma membrane organization GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0010107 potassium ion import GO:0010248 establishment or maintenance of transmembrane electrochemical gradient GO:0010644 cell communication by electrical coupling GO:0010765 positive regulation of sodium ion transport GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling GO:0010959 regulation of metal ion transport GO:0015672 monovalent inorganic cation transport GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0022898 regulation of transmembrane transporter activity GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030007 cellular potassium ion homeostasis GO:0031647 regulation of protein stability GO:0032409 regulation of transporter activity GO:0032411 positive regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032414 positive regulation of ion transmembrane transporter activity GO:0032594 protein transport within lipid bilayer GO:0032596 protein transport into membrane raft GO:0032781 positive regulation of ATPase activity GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035637 multicellular organismal signaling GO:0035725 sodium ion transmembrane transport GO:0036293 response to decreased oxygen levels GO:0036376 sodium ion export from cell GO:0042278 purine nucleoside metabolic process GO:0042391 regulation of membrane potential GO:0043266 regulation of potassium ion transport GO:0043268 positive regulation of potassium ion transport GO:0043270 positive regulation of ion transport GO:0043462 regulation of ATPase activity GO:0044057 regulation of system process GO:0044860 protein localization to plasma membrane raft GO:0044861 protein transport into plasma membrane raft GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0050821 protein stabilization GO:0050900 leukocyte migration GO:0051668 localization within membrane GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0055067 monovalent inorganic cation homeostasis GO:0055074 calcium ion homeostasis GO:0055075 potassium ion homeostasis GO:0055078 sodium ion homeostasis GO:0055117 regulation of cardiac muscle contraction GO:0055119 relaxation of cardiac muscle GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0061337 cardiac conduction GO:0070482 response to oxygen levels GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071436 sodium ion export GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0086001 cardiac muscle cell action potential GO:0086009 membrane repolarization GO:0086011 membrane repolarization during action potential GO:0086013 membrane repolarization during cardiac muscle cell action potential GO:0086064 cell communication by electrical coupling involved in cardiac conduction GO:0086065 cell communication involved in cardiac conduction GO:0090002 establishment of protein localization to plasma membrane GO:0090075 relaxation of muscle GO:0090150 establishment of protein localization to membrane GO:0090257 regulation of muscle system process GO:0090662 ATP hydrolysis coupled transmembrane transport GO:0098657 import into cell GO:0098739 import across plasma membrane GO:0099622 cardiac muscle cell membrane repolarization GO:1901016 regulation of potassium ion transmembrane transporter activity GO:1901018 positive regulation of potassium ion transmembrane transporter activity GO:1901019 regulation of calcium ion transmembrane transporter activity GO:1901021 positive regulation of calcium ion transmembrane transporter activity GO:1901379 regulation of potassium ion transmembrane transport GO:1901381 positive regulation of potassium ion transmembrane transport GO:1901657 glycosyl compound metabolic process GO:1902305 regulation of sodium ion transmembrane transport GO:1902307 positive regulation of sodium ion transmembrane transport GO:1903044 protein localization to membrane raft GO:1903169 regulation of calcium ion transmembrane transport GO:1903273 regulation of sodium ion export GO:1903275 positive regulation of sodium ion export GO:1903276 regulation of sodium ion export from cell GO:1903278 positive regulation of sodium ion export from cell GO:1903279 regulation of calcium:sodium antiporter activity GO:1903281 positive regulation of calcium:sodium antiporter activity GO:1903286 regulation of potassium ion import GO:1903288 positive regulation of potassium ion import GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:1904062 regulation of cation transmembrane transport GO:1904064 positive regulation of cation transmembrane transport GO:1904427 positive regulation of calcium ion transmembrane transport GO:1990573 potassium ion import across plasma membrane GO:1990778 protein localization to cell periphery GO:2000649 regulation of sodium ion transmembrane transporter activity GO:2000651 positive regulation of sodium ion transmembrane transporter activity |
Molecular Function |
GO:0001671 ATPase activator activity GO:0003823 antigen binding GO:0005391 sodium:potassium-exchanging ATPase activity GO:0008022 protein C-terminus binding GO:0008047 enzyme activator activity GO:0008144 drug binding GO:0008556 potassium-transporting ATPase activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0019829 cation-transporting ATPase activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0023023 MHC protein complex binding GO:0023026 MHC class II protein complex binding GO:0030955 potassium ion binding GO:0031402 sodium ion binding GO:0031420 alkali metal ion binding GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0046873 metal ion transmembrane transporter activity GO:0051117 ATPase binding GO:0060589 nucleoside-triphosphatase regulator activity GO:0060590 ATPase regulator activity |
Cellular Component |
GO:0005890 sodium:potassium-exchanging ATPase complex GO:0005901 caveola GO:0014704 intercalated disc GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0042383 sarcolemma GO:0043209 myelin sheath GO:0044291 cell-cell contact zone GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0045177 apical part of cell GO:0090533 cation-transporting ATPase complex GO:0098533 ATPase dependent transmembrane transport complex GO:0098589 membrane region GO:0098857 membrane microdomain GO:1902495 transmembrane transporter complex GO:1904949 ATPase complex GO:1990351 transporter complex |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04260 Cardiac muscle contraction hsa04261 Adrenergic signaling in cardiomyocytes hsa04911 Insulin secretion hsa04918 Thyroid hormone synthesis hsa04919 Thyroid hormone signaling pathway hsa04960 Aldosterone-regulated sodium reabsorption hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04964 Proximal tubule bicarbonate reclamation hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion hsa04973 Carbohydrate digestion and absorption hsa04974 Protein digestion and absorption hsa04976 Bile secretion hsa04978 Mineral absorption |
Reactome |
R-HSA-210991: Basigin interactions R-HSA-5576891: Cardiac conduction R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-983712: Ion channel transport R-HSA-5578775: Ion homeostasis R-HSA-936837: Ion transport by P-type ATPases R-HSA-397014: Muscle contraction R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATP1B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATP1B1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATP1B1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ATP1B1 in various data sets.
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Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP1B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP1B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP1B1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP1B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATP1B1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATP1B1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATP1B1 |
Name | ATPase, Na+/K+ transporting, beta 1 polypeptide |
Aliases | sodium/potassium-transporting ATPase subunit beta-1; sodium pump subunit beta-1; sodium-potassium ATPase sub ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATP1B1 collected from DrugBank database. |
There is no record. |