Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF12424 Plasma membrane calcium transporter ATPase C terminal PF00689 Cation transporting ATPase PF00690 Cation transporter/ATPase |
Function |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. |
Biological Process |
GO:0001654 eye development GO:0003013 circulatory system process GO:0003015 heart process GO:0003407 neural retina development GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007423 sensory organ development GO:0007568 aging GO:0007584 response to nutrient GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009266 response to temperature stimulus GO:0009409 response to cold GO:0009991 response to extracellular stimulus GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0031960 response to corticosteroid GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0035637 multicellular organismal signaling GO:0043010 camera-type eye development GO:0044057 regulation of system process GO:0048545 response to steroid hormone GO:0051384 response to glucocorticoid GO:0051385 response to mineralocorticoid GO:0051412 response to corticosterone GO:0055074 calcium ion homeostasis GO:0060041 retina development in camera-type eye GO:0060047 heart contraction GO:0061337 cardiac conduction GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071295 cellular response to vitamin GO:0071305 cellular response to vitamin D GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071386 cellular response to corticosterone stimulus GO:0071389 cellular response to mineralocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071496 cellular response to external stimulus GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1901660 calcium ion export GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction |
Molecular Function |
GO:0005388 calcium-transporting ATPase activity GO:0005516 calmodulin binding GO:0015085 calcium ion transmembrane transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0019829 cation-transporting ATPase activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0030165 PDZ domain binding GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0046873 metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0009898 cytoplasmic side of plasma membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032589 neuron projection membrane GO:0032590 dendrite membrane GO:0032591 dendritic spine membrane GO:0032809 neuronal cell body membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0044298 cell body membrane GO:0045121 membrane raft GO:0045177 apical part of cell GO:0097060 synaptic membrane GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04020 Calcium signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04970 Salivary secretion hsa04972 Pancreatic secretion hsa04978 Mineral absorption |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-109582: Hemostasis R-HSA-983712: Ion channel transport R-HSA-5578775: Ion homeostasis R-HSA-936837: Ion transport by P-type ATPases R-HSA-397014: Muscle contraction R-HSA-418360: Platelet calcium homeostasis R-HSA-418346: Platelet homeostasis R-HSA-418359: Reduction of cytosolic Ca++ levels R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATP2B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ATP2B1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATP2B1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of ATP2B1 in various data sets.
|
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP2B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP2B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP2B1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP2B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATP2B1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATP2B1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ATP2B1 |
Name | ATPase, Ca++ transporting, plasma membrane 1 |
Aliases | PMCA1; plasma membrane calcium-transporting ATPase 1; PMCA1kb; Plasma membrane calcium pump isoform 1; Plasm ...... |
Chromosomal Location | 12q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATP2B1 collected from DrugBank database. |
There is no record. |