Browse ATP6V0C

Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Vacuole membrane; Multi-pass membrane protein.
Domain PF00137 ATP synthase subunit C
Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

> Gene Ontology
 
Biological Process GO:0000041 transition metal ion transport
GO:0006818 hydrogen transport
GO:0006826 iron ion transport
GO:0006885 regulation of pH
GO:0006914 autophagy
GO:0007033 vacuole organization
GO:0007035 vacuolar acidification
GO:0007040 lysosome organization
GO:0007042 lysosomal lumen acidification
GO:0008286 insulin receptor signaling pathway
GO:0010506 regulation of autophagy
GO:0015672 monovalent inorganic cation transport
GO:0015682 ferric iron transport
GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0016055 Wnt signaling pathway
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030641 regulation of cellular pH
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033572 transferrin transport
GO:0035751 regulation of lysosomal lumen pH
GO:0043434 response to peptide hormone
GO:0045851 pH reduction
GO:0051452 intracellular pH reduction
GO:0051453 regulation of intracellular pH
GO:0055067 monovalent inorganic cation homeostasis
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0072512 trivalent inorganic cation transport
GO:0080171 lytic vacuole organization
GO:0090382 phagosome maturation
GO:0090383 phagosome acidification
GO:0090662 ATP hydrolysis coupled transmembrane transport
GO:0198738 cell-cell signaling by wnt
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902600 hydrogen ion transmembrane transport
Molecular Function GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding
GO:0036442 hydrogen-exporting ATPase activity
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
GO:0044389 ubiquitin-like protein ligase binding
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Cellular Component GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005765 lysosomal membrane
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0010008 endosome membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0030055 cell-substrate junction
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0033176 proton-transporting V-type ATPase complex
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0044440 endosomal part
GO:0045335 phagocytic vesicle
GO:0098852 lytic vacuole membrane
> KEGG and Reactome Pathway
 
KEGG hsa04142 Lysosome
hsa04145 Phagosome
hsa04721 Synaptic vesicle cycle
hsa04966 Collecting duct acid secretion
hsa00190 Oxidative phosphorylation
hsa01100 Metabolic pathways
Reactome R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-77387: Insulin receptor recycling
R-HSA-983712: Ion channel transport
R-HSA-917937: Iron uptake and transport
R-HSA-6798695: Neutrophil degranulation
R-HSA-1222556: ROS, RNS production in phagocytes
R-HSA-162582: Signal Transduction
R-HSA-74752: Signaling by Insulin receptor
R-HSA-917977: Transferrin endocytosis and recycling
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP6V0C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP6V0C in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.6 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP6V0C in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2960.394
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3240.935
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2740.925
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2540.377
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.010.996
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5630.821
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0130.973
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2920.637
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2010.751
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4820.822
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3490.917
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0270.646
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP6V0C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP6V0C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP6V0C.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP6V0C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP6V0C expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP6V0C and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP6V0C
NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Aliases VATL; Vma3; ATPL; ATP6L; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD; VPPC; H(+)-transpor ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP6V0C collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.