Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF03179 Vacuolar (H+)-ATPase G subunit |
Function |
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. |
Biological Process |
GO:0000041 transition metal ion transport GO:0006818 hydrogen transport GO:0006826 iron ion transport GO:0006885 regulation of pH GO:0008286 insulin receptor signaling pathway GO:0015672 monovalent inorganic cation transport GO:0015682 ferric iron transport GO:0015992 proton transport GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030641 regulation of cellular pH GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033572 transferrin transport GO:0043434 response to peptide hormone GO:0045851 pH reduction GO:0051452 intracellular pH reduction GO:0051453 regulation of intracellular pH GO:0055067 monovalent inorganic cation homeostasis GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0072512 trivalent inorganic cation transport GO:0090382 phagosome maturation GO:0090383 phagosome acidification GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902600 hydrogen ion transmembrane transport |
Molecular Function |
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015078 hydrogen ion transmembrane transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0019829 cation-transporting ATPase activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0036442 hydrogen-exporting ATPase activity GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0051117 ATPase binding |
Cellular Component |
GO:0016469 proton-transporting two-sector ATPase complex GO:0016471 vacuolar proton-transporting V-type ATPase complex GO:0033176 proton-transporting V-type ATPase complex |
KEGG |
hsa04145 Phagosome hsa04150 mTOR signaling pathway hsa04721 Synaptic vesicle cycle hsa04966 Collecting duct acid secretion hsa00190 Oxidative phosphorylation hsa01100 Metabolic pathways |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-77387: Insulin receptor recycling R-HSA-983712: Ion channel transport R-HSA-917937: Iron uptake and transport R-HSA-1222556: ROS, RNS production in phagocytes R-HSA-162582: Signal Transduction R-HSA-74752: Signaling by Insulin receptor R-HSA-917977: Transferrin endocytosis and recycling R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATP6V1G3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATP6V1G3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATP6V1G3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ATP6V1G3 in various data sets.
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Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP6V1G3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP6V1G3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP6V1G3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP6V1G3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATP6V1G3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATP6V1G3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATP6V1G3 |
Name | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 |
Aliases | ATP6G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3; ATPase, H+ transporting, lysosomal ...... |
Chromosomal Location | 1q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATP6V1G3 collected from DrugBank database. |
There is no record. |