Summary | |
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Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF11698 V-ATPase subunit H |
Function |
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. |
Biological Process |
GO:0000041 transition metal ion transport GO:0002697 regulation of immune effector process GO:0002831 regulation of response to biotic stimulus GO:0006818 hydrogen transport GO:0006826 iron ion transport GO:0006885 regulation of pH GO:0006914 autophagy GO:0007035 vacuolar acidification GO:0008286 insulin receptor signaling pathway GO:0009615 response to virus GO:0010506 regulation of autophagy GO:0015672 monovalent inorganic cation transport GO:0015682 ferric iron transport GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient GO:0015991 ATP hydrolysis coupled proton transport GO:0015992 proton transport GO:0016236 macroautophagy GO:0016241 regulation of macroautophagy GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030641 regulation of cellular pH GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033572 transferrin transport GO:0043434 response to peptide hormone GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0045851 pH reduction GO:0050688 regulation of defense response to virus GO:0050690 regulation of defense response to virus by virus GO:0050792 regulation of viral process GO:0051452 intracellular pH reduction GO:0051453 regulation of intracellular pH GO:0051607 defense response to virus GO:0055067 monovalent inorganic cation homeostasis GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0072512 trivalent inorganic cation transport GO:0090382 phagosome maturation GO:0090383 phagosome acidification GO:0090662 ATP hydrolysis coupled transmembrane transport GO:0098542 defense response to other organism GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902600 hydrogen ion transmembrane transport |
Molecular Function |
GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015078 hydrogen ion transmembrane transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0019829 cation-transporting ATPase activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0036442 hydrogen-exporting ATPase activity GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism GO:0046961 proton-transporting ATPase activity, rotational mechanism |
Cellular Component |
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain GO:0005765 lysosomal membrane GO:0016469 proton-transporting two-sector ATPase complex GO:0016471 vacuolar proton-transporting V-type ATPase complex GO:0033176 proton-transporting V-type ATPase complex GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain GO:0033180 proton-transporting V-type ATPase, V1 domain GO:0098852 lytic vacuole membrane |
KEGG |
hsa04142 Lysosome hsa04145 Phagosome hsa04150 mTOR signaling pathway hsa04721 Synaptic vesicle cycle hsa00190 Oxidative phosphorylation hsa01100 Metabolic pathways |
Reactome |
R-HSA-1643685: Disease R-HSA-162906: HIV Infection R-HSA-162909: Host Interactions of HIV factors R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168249: Innate Immune System R-HSA-77387: Insulin receptor recycling R-HSA-983712: Ion channel transport R-HSA-917937: Iron uptake and transport R-HSA-167590: Nef Mediated CD4 Down-regulation R-HSA-182218: Nef Mediated CD8 Down-regulation R-HSA-164938: Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-1222556: ROS, RNS production in phagocytes R-HSA-162582: Signal Transduction R-HSA-74752: Signaling by Insulin receptor R-HSA-164952: The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-917977: Transferrin endocytosis and recycling R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATP6V1H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATP6V1H in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATP6V1H in various data sets.
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Points in the above scatter plot represent the mutation difference of ATP6V1H in various data sets.
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Summary | |
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Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP6V1H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP6V1H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP6V1H. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP6V1H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATP6V1H expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATP6V1H and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATP6V1H |
Name | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Aliases | CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ...... |
Chromosomal Location | 8q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATP6V1H collected from DrugBank database. |
There is no record. |