Browse ATP8A2

Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein Golgi apparatus Endosome Cell projection, cilium, photoreceptor outer segment Cell membrane Note=Localizes to the Golgi and endosomes in photoreceptor cells. Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity).
Domain PF16212 Phospholipid-translocating P-type ATPase C-terminal
PF16209 Phospholipid-translocating ATPase N-terminal
Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0003009 skeletal muscle contraction
GO:0003011 involuntary skeletal muscle contraction
GO:0003012 muscle system process
GO:0003407 neural retina development
GO:0006869 lipid transport
GO:0006900 membrane budding
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007409 axonogenesis
GO:0007423 sensory organ development
GO:0007568 aging
GO:0007601 visual perception
GO:0007631 feeding behavior
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009583 detection of light stimulus
GO:0009584 detection of visible light
GO:0009612 response to mechanical stimulus
GO:0010720 positive regulation of cell development
GO:0010842 retina layer formation
GO:0010876 lipid localization
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0010996 response to auditory stimulus
GO:0015748 organophosphate ester transport
GO:0015914 phospholipid transport
GO:0016050 vesicle organization
GO:0031346 positive regulation of cell projection organization
GO:0032368 regulation of lipid transport
GO:0032370 positive regulation of lipid transport
GO:0034204 lipid translocation
GO:0035264 multicellular organism growth
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042755 eating behavior
GO:0043010 camera-type eye development
GO:0043583 ear development
GO:0043588 skin development
GO:0045103 intermediate filament-based process
GO:0045104 intermediate filament cytoskeleton organization
GO:0045332 phospholipid translocation
GO:0045666 positive regulation of neuron differentiation
GO:0045927 positive regulation of growth
GO:0048193 Golgi vesicle transport
GO:0048194 Golgi vesicle budding
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048839 inner ear development
GO:0050769 positive regulation of neurogenesis
GO:0050879 multicellular organismal movement
GO:0050881 musculoskeletal movement
GO:0050884 neuromuscular process controlling posture
GO:0050905 neuromuscular process
GO:0050908 detection of light stimulus involved in visual perception
GO:0050953 sensory perception of light stimulus
GO:0050962 detection of light stimulus involved in sensory perception
GO:0051962 positive regulation of nervous system development
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0060052 neurofilament cytoskeleton organization
GO:0061091 regulation of phospholipid translocation
GO:0061092 positive regulation of phospholipid translocation
GO:0061564 axon development
GO:0090596 sensory organ morphogenesis
GO:0097035 regulation of membrane lipid distribution
GO:2001138 regulation of phospholipid transport
GO:2001140 positive regulation of phospholipid transport
Molecular Function GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005319 lipid transporter activity
GO:0005548 phospholipid transporter activity
GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
GO:0043492 ATPase activity, coupled to movement of substances
Cellular Component GO:0001750 photoreceptor outer segment
GO:0005802 trans-Golgi network
GO:0005929 cilium
GO:0031513 nonmotile primary cilium
GO:0031984 organelle subcompartment
GO:0072372 primary cilium
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-983712: Ion channel transport
R-HSA-936837: Ion transport by P-type ATPases
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP8A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP8A2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP8A2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.0250.00561
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.910.159
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.1080.0393
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0060.992
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2160.86
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2610.855
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6410.361
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.4260.181
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4830.644
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.390.341
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4120.457
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1690.446
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATP8A2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.12.78.40.12
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP8A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP8A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP8A2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP8A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP8A2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP8A2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP8A2
NameATPase, aminophospholipid transporter, class I, type 8A, member 2
Aliases ATPIB; ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2; ATP; CAMRQ4; IB; P4-ATPase fl ......
Chromosomal Location13q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP8A2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.