Summary | |
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Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Nucleus, PML body Chromosome Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling. |
Domain |
PF02259 FAT domain PF02260 FATC domain PF00454 Phosphatidylinositol 3- and 4-kinase PF08064 UME (NUC010) domain |
Function |
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000723 telomere maintenance GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006278 RNA-dependent DNA biosynthetic process GO:0006403 RNA localization GO:0007004 telomere maintenance via telomerase GO:0007568 aging GO:0007569 cell aging GO:0008156 negative regulation of DNA replication GO:0009266 response to temperature stimulus GO:0009314 response to radiation GO:0009408 response to heat GO:0009411 response to UV GO:0009416 response to light stimulus GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0010833 telomere maintenance via telomere lengthening GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031570 DNA integrity checkpoint GO:0032200 telomere organization GO:0032204 regulation of telomere maintenance GO:0032206 positive regulation of telomere maintenance GO:0032210 regulation of telomere maintenance via telomerase GO:0032212 positive regulation of telomere maintenance via telomerase GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033044 regulation of chromosome organization GO:0034502 protein localization to chromosome GO:0034605 cellular response to heat GO:0034644 cellular response to UV GO:0036297 interstrand cross-link repair GO:0042493 response to drug GO:0042770 signal transduction in response to DNA damage GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0044089 positive regulation of cellular component biogenesis GO:0046777 protein autophosphorylation GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051236 establishment of RNA localization GO:0060249 anatomical structure homeostasis GO:0070198 protein localization to chromosome, telomeric region GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071480 cellular response to gamma radiation GO:0071482 cellular response to light stimulus GO:0071826 ribonucleoprotein complex subunit organization GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:0090399 replicative senescence GO:0097694 establishment of RNA localization to telomere GO:0097695 establishment of macromolecular complex localization to telomere GO:1900034 regulation of cellular response to heat GO:1901796 regulation of signal transduction by p53 class mediator GO:1901798 positive regulation of signal transduction by p53 class mediator GO:1904356 regulation of telomere maintenance via telomere lengthening GO:1904358 positive regulation of telomere maintenance via telomere lengthening GO:1904868 telomerase catalytic core complex assembly GO:1904882 regulation of telomerase catalytic core complex assembly GO:1904884 positive regulation of telomerase catalytic core complex assembly GO:1905323 telomerase holoenzyme complex assembly GO:2000278 regulation of DNA biosynthetic process GO:2000573 positive regulation of DNA biosynthetic process GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001252 positive regulation of chromosome organization |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0032404 mismatch repair complex binding GO:0032405 MutLalpha complex binding GO:0032407 MutSalpha complex binding |
Cellular Component |
GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0016604 nuclear body GO:0016605 PML body GO:0044454 nuclear chromosome part GO:0098687 chromosomal region |
KEGG |
hsa03460 Fanconi anemia pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway |
Reactome |
R-HSA-176187: Activation of ATR in response to replication stress R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-3371556: Cellular response to heat stress R-HSA-2262752: Cellular responses to stress R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-6783310: Fanconi Anemia Pathway R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5685942: HDR through Homologous Recombination (HRR) R-HSA-5685938: HDR through Single Strand Annealing (SSA) R-HSA-5693579: Homologous DNA Pairing and Strand Exchange R-HSA-5693538: Homology Directed Repair R-HSA-1500620: Meiosis R-HSA-1221632: Meiotic synapsis R-HSA-5693616: Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693607: Processing of DNA double-strand break ends R-HSA-3371453: Regulation of HSF1-mediated heat shock response R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ATR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ATR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ATR in various data sets.
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Points in the above scatter plot represent the mutation difference of ATR in various data sets.
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Summary | |
---|---|
Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ATR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ATR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ATR |
Name | ATR serine/threonine kinase |
Aliases | SCKL; SCKL1; MEC1; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); ataxia telangiectasia and Rad3 ...... |
Chromosomal Location | 3q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ATR collected from DrugBank database. |
There is no record. |