Summary | |
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Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type III membrane protein Cytoplasmic side |
Domain |
PF02845 CUE domain |
Function |
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. |
Biological Process |
GO:0010498 proteasomal protein catabolic process GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030970 retrograde protein transport, ER to cytosol GO:0032527 protein exit from endoplasmic reticulum GO:0034976 response to endoplasmic reticulum stress GO:0036503 ERAD pathway GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:1903513 endoplasmic reticulum to cytosol transport |
Molecular Function |
GO:0032182 ubiquitin-like protein binding GO:0043130 ubiquitin binding GO:0055103 ligase regulator activity GO:0055106 ubiquitin-protein transferase regulator activity GO:0097027 ubiquitin-protein transferase activator activity |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0000153 cytoplasmic ubiquitin ligase complex GO:0000835 ER ubiquitin ligase complex GO:0000836 Hrd1p ubiquitin ligase complex GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AUP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AUP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AUP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of AUP1 in various data sets.
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Summary | |
---|---|
Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AUP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AUP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AUP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AUP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AUP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AUP1 |
Name | ancient ubiquitous protein 1 |
Aliases | |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AUP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |