Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). |
Domain |
PF00069 Protein kinase domain |
Function |
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000086 G2/M transition of mitotic cell cycle GO:0000212 meiotic spindle organization GO:0000226 microtubule cytoskeleton organization GO:0000910 cytokinesis GO:0001556 oocyte maturation GO:0003002 regionalization GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007051 spindle organization GO:0007052 mitotic spindle organization GO:0007056 spindle assembly involved in female meiosis GO:0007057 spindle assembly involved in female meiosis I GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007093 mitotic cell cycle checkpoint GO:0007098 centrosome cycle GO:0007100 mitotic centrosome separation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007143 female meiotic division GO:0007144 female meiosis I GO:0007281 germ cell development GO:0007292 female gamete generation GO:0007346 regulation of mitotic cell cycle GO:0007389 pattern specification process GO:0009798 axis specification GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0009994 oocyte differentiation GO:0010498 proteasomal protein catabolic process GO:0010720 positive regulation of cell development GO:0010948 negative regulation of cell cycle process GO:0016049 cell growth GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0021700 developmental maturation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031023 microtubule organizing center organization GO:0031145 anaphase-promoting complex-dependent catabolic process GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031647 regulation of protein stability GO:0032091 negative regulation of protein binding GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032465 regulation of cytokinesis GO:0032886 regulation of microtubule-based process GO:0035404 histone-serine phosphorylation GO:0042176 regulation of protein catabolic process GO:0042770 signal transduction in response to DNA damage GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043393 regulation of protein binding GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0044380 protein localization to cytoskeleton GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044839 cell cycle G2/M phase transition GO:0044843 cell cycle G1/S phase transition GO:0045732 positive regulation of protein catabolic process GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045840 positive regulation of mitotic nuclear division GO:0045862 positive regulation of proteolysis GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0046605 regulation of centrosome cycle GO:0046777 protein autophosphorylation GO:0048469 cell maturation GO:0048477 oogenesis GO:0048588 developmental cell growth GO:0048599 oocyte development GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051225 spindle assembly GO:0051297 centrosome organization GO:0051299 centrosome separation GO:0051302 regulation of cell division GO:0051321 meiotic cell cycle GO:0051493 regulation of cytoskeleton organization GO:0051640 organelle localization GO:0051642 centrosome localization GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0060281 regulation of oocyte development GO:0060282 positive regulation of oocyte development GO:0060560 developmental growth involved in morphogenesis GO:0061136 regulation of proteasomal protein catabolic process GO:0070507 regulation of microtubule cytoskeleton organization GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071539 protein localization to centrosome GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0072698 protein localization to microtubule cytoskeleton GO:0090068 positive regulation of cell cycle process GO:0090306 spindle assembly involved in meiosis GO:1900193 regulation of oocyte maturation GO:1900195 positive regulation of oocyte maturation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901800 positive regulation of proteasomal protein catabolic process GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903046 meiotic cell cycle process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903429 regulation of cell maturation GO:1903431 positive regulation of cell maturation GO:1990138 neuron projection extension GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000241 regulation of reproductive process GO:2000243 positive regulation of reproductive process |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004712 protein serine/threonine/tyrosine kinase activity GO:0031625 ubiquitin protein ligase binding GO:0035173 histone kinase activity GO:0035174 histone serine kinase activity GO:0044389 ubiquitin-like protein ligase binding |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000779 condensed chromosome, centromeric region GO:0000780 condensed nuclear chromosome, centromeric region GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000922 spindle pole GO:0001674 female germ cell nucleus GO:0005813 centrosome GO:0005814 centriole GO:0005819 spindle GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005876 spindle microtubule GO:0005929 cilium GO:0030424 axon GO:0030496 midbody GO:0031616 spindle pole centrosome GO:0032133 chromosome passenger complex GO:0033267 axon part GO:0042585 germinal vesicle GO:0043025 neuronal cell body GO:0043073 germ cell nucleus GO:0043203 axon hillock GO:0044297 cell body GO:0044450 microtubule organizing center part GO:0044454 nuclear chromosome part GO:0045120 pronucleus GO:0051233 spindle midzone GO:0072686 mitotic spindle GO:0072687 meiotic spindle GO:0098687 chromosomal region |
KEGG |
hsa04114 Oocyte meiosis |
Reactome |
R-HSA-174143: APC/C-mediated degradation of cell cycle proteins R-HSA-174178: APC/C R-HSA-8854518: AURKA Activation by TPX2 R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-8854050: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-69275: G2/M Transition R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-8854521: Interaction between PHLDA1 and AURKA R-HSA-392499: Metabolism of proteins R-HSA-453274: Mitotic G2-G2/M phases R-HSA-597592: Post-translational protein modification R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-453276: Regulation of mitotic cell cycle R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-4615885: SUMOylation of DNA replication proteins R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AURKA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between AURKA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AURKA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AURKA in various data sets.
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Points in the above scatter plot represent the mutation difference of AURKA in various data sets.
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Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AURKA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AURKA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AURKA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AURKA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AURKA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AURKA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | AURKA |
Name | aurora kinase A |
Aliases | BTAK; AurA; ARK1; PPP1R47; AIK; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; STK15; STK6; ...... |
Chromosomal Location | 20q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AURKA collected from DrugBank database. |
Details on drugs targeting AURKA.
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