Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Membrane Cell membrane Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684). |
Domain |
PF16646 Axin-1 tankyrase binding domain PF08833 Axin beta-catenin binding domain PF00778 DIX domain PF00615 Regulator of G protein signaling domain |
Function |
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). |
Biological Process |
GO:0000187 activation of MAPK activity GO:0000226 microtubule cytoskeleton organization GO:0001501 skeletal system development GO:0001654 eye development GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001743 optic placode formation GO:0001756 somitogenesis GO:0003002 regionalization GO:0006354 DNA-templated transcription, elongation GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007254 JNK cascade GO:0007257 activation of JUN kinase activity GO:0007368 determination of left/right symmetry GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0009798 axis specification GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009950 dorsal/ventral axis specification GO:0009952 anterior/posterior pattern specification GO:0009953 dorsal/ventral pattern formation GO:0010498 proteasomal protein catabolic process GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0016055 Wnt signaling pathway GO:0017038 protein import GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0021797 forebrain anterior/posterior pattern specification GO:0021871 forebrain regionalization GO:0021872 forebrain generation of neurons GO:0021877 forebrain neuron fate commitment GO:0021879 forebrain neuron differentiation GO:0021881 Wnt-activated signaling pathway involved in forebrain neuron fate commitment GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain GO:0021953 central nervous system neuron differentiation GO:0021999 neural plate anterior/posterior regionalization GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030900 forebrain development GO:0030910 olfactory placode formation GO:0031098 stress-activated protein kinase signaling cascade GO:0031122 cytoplasmic microtubule organization GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0032147 activation of protein kinase activity GO:0032386 regulation of intracellular transport GO:0032784 regulation of DNA-templated transcription, elongation GO:0032785 negative regulation of DNA-templated transcription, elongation GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032984 macromolecular complex disassembly GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033674 positive regulation of kinase activity GO:0034243 regulation of transcription elongation from RNA polymerase II promoter GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter GO:0034504 protein localization to nucleus GO:0035282 segmentation GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0042176 regulation of protein catabolic process GO:0042306 regulation of protein import into nucleus GO:0042692 muscle cell differentiation GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043241 protein complex disassembly GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0043584 nose development GO:0044744 protein targeting to nucleus GO:0045165 cell fate commitment GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045732 positive regulation of protein catabolic process GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046822 regulation of nucleocytoplasmic transport GO:0048048 embryonic eye morphogenesis GO:0048318 axial mesoderm development GO:0048319 axial mesoderm morphogenesis GO:0048320 axial mesoderm formation GO:0048332 mesoderm morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048663 neuron fate commitment GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051403 stress-activated MAPK cascade GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051443 positive regulation of ubiquitin-protein transferase activity GO:0055001 muscle cell development GO:0060070 canonical Wnt signaling pathway GO:0060272 embryonic skeletal joint morphogenesis GO:0060541 respiratory system development GO:0060788 ectodermal placode formation GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation GO:0060828 regulation of canonical Wnt signaling pathway GO:0060896 neural plate pattern specification GO:0060897 neural plate regionalization GO:0061053 somite development GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0071407 cellular response to organic cyclic compound GO:0071696 ectodermal placode development GO:0071697 ectodermal placode morphogenesis GO:0071698 olfactory placode development GO:0071699 olfactory placode morphogenesis GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072498 embryonic skeletal joint development GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090244 Wnt signaling pathway involved in somitogenesis GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090596 sensory organ morphogenesis GO:0198738 cell-cell signaling by wnt GO:1900180 regulation of protein localization to nucleus GO:1902593 single-organism nuclear import GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903533 regulation of protein targeting GO:1904589 regulation of protein import GO:1904885 beta-catenin destruction complex assembly GO:1904886 beta-catenin destruction complex disassembly GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
Molecular Function |
GO:0005096 GTPase activator activity GO:0008013 beta-catenin binding GO:0008047 enzyme activator activity GO:0030159 receptor signaling complex scaffold activity GO:0030695 GTPase regulator activity GO:0031625 ubiquitin protein ligase binding GO:0032947 protein complex scaffold GO:0044389 ubiquitin-like protein ligase binding GO:0046332 SMAD binding GO:0060589 nucleoside-triphosphatase regulator activity GO:0070016 armadillo repeat domain binding GO:0070411 I-SMAD binding |
Cellular Component |
GO:0005874 microtubule GO:0005881 cytoplasmic microtubule GO:0005938 cell cortex GO:0014069 postsynaptic density GO:0016328 lateral plasma membrane GO:0030877 beta-catenin destruction complex GO:0060076 excitatory synapse GO:0098794 postsynapse GO:0099568 cytoplasmic region GO:0099572 postsynaptic specialization |
KEGG |
hsa04310 Wnt signaling pathway hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-4839748: AMER1 mutants destabilize the destruction complex R-HSA-5467337: APC truncation mutants have impaired AXIN binding R-HSA-5467340: AXIN missense mutants destabilize the destruction complex R-HSA-4839735: AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-196299: Beta-catenin phosphorylation cascade R-HSA-4641257: Degradation of AXIN R-HSA-195253: Degradation of beta-catenin by the destruction complex R-HSA-5467345: Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling R-HSA-5688426: Deubiquitination R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-392499: Metabolism of proteins R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-597592: Post-translational protein modification R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated R-HSA-162582: Signal Transduction R-HSA-4791275: Signaling by WNT in cancer R-HSA-195721: Signaling by Wnt R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5467348: Truncations of AMER1 destabilize the destruction complex R-HSA-5689880: Ub-specific processing proteases R-HSA-4839743: phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-4839744: truncated APC mutants destabilize the destruction complex |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AXIN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AXIN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AXIN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of AXIN1 in various data sets.
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Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AXIN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AXIN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AXIN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AXIN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AXIN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AXIN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | AXIN1 |
Name | axin 1 |
Aliases | PPP1R49; protein phosphatase 1, regulatory subunit 49; AXIN; axis inhibition protein 1; axis inhibitor 1; fu ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AXIN1 collected from DrugBank database. |
Details on drugs targeting AXIN1.
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