Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type II membrane protein |
Domain |
PF02434 Fringe-like |
Function |
O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006004 fucose metabolic process GO:0006486 protein glycosylation GO:0006493 protein O-linked glycosylation GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0019318 hexose metabolic process GO:0036065 fucosylation GO:0036066 protein O-linked fucosylation GO:0043413 macromolecule glycosylation GO:0044723 single-organism carbohydrate metabolic process GO:0070085 glycosylation |
Molecular Function |
GO:0016757 transferase activity, transferring glycosyl groups |
Cellular Component | - |
KEGG |
hsa00514 Other types of O-glycan biosynthesis |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-5173214: O-glycosylation of TSR domain-containing proteins R-HSA-5173105: O-linked glycosylation R-HSA-597592: Post-translational protein modification |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between B3GLCT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of B3GLCT in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of B3GLCT in various data sets.
|
Points in the above scatter plot represent the mutation difference of B3GLCT in various data sets.
|
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of B3GLCT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of B3GLCT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by B3GLCT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of B3GLCT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of B3GLCT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between B3GLCT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | B3GLCT |
Name | beta 3-glucosyltransferase |
Aliases | B3GTL; B3Glc-T; B3GALTL; beta 1,3-galactosyltransferase-like; Gal-T; beta3Glc-T; UDP-GAL:beta-GlcNAc beta-1, ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting B3GLCT collected from DrugBank database. |
There is no record. |