Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain | - |
Function |
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). |
Biological Process |
GO:0006457 protein folding GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0034605 cellular response to heat GO:1900034 regulation of cellular response to heat |
Molecular Function |
GO:0000774 adenyl-nucleotide exchange factor activity GO:0051087 chaperone binding GO:0060589 nucleoside-triphosphatase regulator activity GO:0060590 ATPase regulator activity |
Cellular Component | - |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-3371556: Cellular response to heat stress R-HSA-2262752: Cellular responses to stress R-HSA-3371453: Regulation of HSF1-mediated heat shock response |
Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BAG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BAG2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BAG2 in various data sets.
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Points in the above scatter plot represent the mutation difference of BAG2 in various data sets.
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Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BAG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BAG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BAG2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BAG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BAG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BAG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | BAG2 |
Name | BCL2-associated athanogene 2 |
Aliases | BAG-2; dJ417I1.2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG- ...... |
Chromosomal Location | 6p12.3-p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BAG2 collected from DrugBank database. |
There is no record. |