Browse BAHD1

Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Chromosome Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3).
Domain PF01426 BAH domain
Function

Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.

> Gene Ontology
 
Biological Process GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006338 chromatin remodeling
GO:0006342 chromatin silencing
GO:0016458 gene silencing
GO:0031497 chromatin assembly
GO:0031507 heterochromatin assembly
GO:0040029 regulation of gene expression, epigenetic
GO:0045814 negative regulation of gene expression, epigenetic
GO:0070828 heterochromatin organization
GO:0071103 DNA conformation change
Molecular Function GO:0003682 chromatin binding
Cellular Component GO:0000785 chromatin
GO:0005677 chromatin silencing complex
GO:0017053 transcriptional repressor complex
GO:0090568 nuclear transcriptional repressor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BAHD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BAHD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BAHD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5830.0346
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.210.449
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1280.912
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4950.238
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3490.856
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6810.782
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2910.368
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4410.746
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1490.92
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.520.652
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7050.668
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0240.726
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BAHD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BAHD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BAHD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BAHD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BAHD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BAHD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BAHD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBAHD1
Namebromo adjacent homology domain containing 1
Aliases KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein
Chromosomal Location15q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BAHD1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.