Summary | |
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Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3). |
Domain |
PF01426 BAH domain |
Function |
Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0016458 gene silencing GO:0031497 chromatin assembly GO:0031507 heterochromatin assembly GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0070828 heterochromatin organization GO:0071103 DNA conformation change |
Molecular Function |
GO:0003682 chromatin binding |
Cellular Component |
GO:0000785 chromatin GO:0005677 chromatin silencing complex GO:0017053 transcriptional repressor complex GO:0090568 nuclear transcriptional repressor complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BAHD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BAHD1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BAHD1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BAHD1 in various data sets.
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Summary | |
---|---|
Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BAHD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BAHD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BAHD1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BAHD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BAHD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BAHD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BAHD1 |
Name | bromo adjacent homology domain containing 1 |
Aliases | KIAA0945; BAH domain-containing protein 1; Bromo adjacent homology domain-containing 1 protein |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BAHD1 collected from DrugBank database. |
There is no record. |