Summary | |
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Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. |
Domain |
PF08397 IRSp53/MIM homology domain PF14604 Variant SH3 domain |
Function |
May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. |
Biological Process |
GO:0007009 plasma membrane organization GO:0007015 actin filament organization GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0008286 insulin receptor signaling pathway GO:0030041 actin filament polymerization GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030838 positive regulation of actin filament polymerization GO:0031334 positive regulation of protein complex assembly GO:0031532 actin cytoskeleton reorganization GO:0032271 regulation of protein polymerization GO:0032273 positive regulation of protein polymerization GO:0032535 regulation of cellular component size GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0043254 regulation of protein complex assembly GO:0043434 response to peptide hormone GO:0044089 positive regulation of cellular component biogenesis GO:0046626 regulation of insulin receptor signaling pathway GO:0051017 actin filament bundle assembly GO:0051258 protein polymerization GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051764 actin crosslink formation GO:0061572 actin filament bundle organization GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0090066 regulation of anatomical structure size GO:1900076 regulation of cellular response to insulin stimulus GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:2000249 regulation of actin cytoskeleton reorganization GO:2000251 positive regulation of actin cytoskeleton reorganization |
Molecular Function |
GO:0003779 actin binding GO:0008093 cytoskeletal adaptor activity GO:0030674 protein binding, bridging GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0060090 binding, bridging GO:0070064 proline-rich region binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0015629 actin cytoskeleton |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BAIAP2L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BAIAP2L1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BAIAP2L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BAIAP2L1 in various data sets.
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Summary | |
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Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BAIAP2L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BAIAP2L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BAIAP2L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BAIAP2L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BAIAP2L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BAIAP2L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BAIAP2L1 |
Name | BAI1-associated protein 2-like 1 |
Aliases | IRTKS; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; Brain-specific ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BAIAP2L1 collected from DrugBank database. |
There is no record. |