Browse BAX

Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.; SUBCELLULAR LOCATION: Isoform Beta: Cytoplasm.; SUBCELLULAR LOCATION: Isoform Gamma: Cytoplasm.; SUBCELLULAR LOCATION: Isoform Delta: Cytoplasm
Domain PF00452 Apoptosis regulator proteins
Function

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001569 patterning of blood vessels
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001763 morphogenesis of a branching structure
GO:0001764 neuron migration
GO:0001776 leukocyte homeostasis
GO:0001777 T cell homeostatic proliferation
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001894 tissue homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0001974 blood vessel remodeling
GO:0002260 lymphocyte homeostasis
GO:0002262 myeloid cell homeostasis
GO:0002339 B cell selection
GO:0002352 B cell negative selection
GO:0002358 B cell homeostatic proliferation
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002521 leukocyte differentiation
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0002904 positive regulation of B cell apoptotic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0006643 membrane lipid metabolic process
GO:0006664 glycolipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006816 calcium ion transport
GO:0006839 mitochondrial transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0006970 response to osmotic stress
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006986 response to unfolded protein
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007006 mitochondrial membrane organization
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007346 regulation of mitotic cell cycle
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007548 sex differentiation
GO:0008053 mitochondrial fusion
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637 apoptotic mitochondrial changes
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009566 fertilization
GO:0009636 response to toxic substance
GO:0009651 response to salt stress
GO:0009791 post-embryonic development
GO:0009886 post-embryonic animal morphogenesis
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010212 response to ionizing radiation
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010623 programmed cell death involved in cell development
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010948 negative regulation of cell cycle process
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0010959 regulation of metal ion transport
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0019439 aromatic compound catabolic process
GO:0019740 nitrogen utilization
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021761 limbic system development
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022602 ovulation cycle process
GO:0022612 gland morphogenesis
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030262 apoptotic nuclear changes
GO:0030326 embryonic limb morphogenesis
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030540 female genitalia development
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031077 post-embryonic camera-type eye development
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031334 positive regulation of protein complex assembly
GO:0031570 DNA integrity checkpoint
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032069 regulation of nuclease activity
GO:0032075 positive regulation of nuclease activity
GO:0032091 negative regulation of protein binding
GO:0032459 regulation of protein oligomerization
GO:0032461 positive regulation of protein oligomerization
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032943 mononuclear cell proliferation
GO:0032976 release of matrix enzymes from mitochondria
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033598 mammary gland epithelial cell proliferation
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0034103 regulation of tissue remodeling
GO:0034105 positive regulation of tissue remodeling
GO:0034620 cellular response to unfolded protein
GO:0034644 cellular response to UV
GO:0034655 nucleobase-containing compound catabolic process
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0034976 response to endoplasmic reticulum stress
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035234 ectopic germ cell programmed cell death
GO:0035239 tube morphogenesis
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036498 IRE1-mediated unfolded protein response
GO:0038034 signal transduction in absence of ligand
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042326 negative regulation of phosphorylation
GO:0042391 regulation of membrane potential
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042698 ovulation cycle
GO:0042733 embryonic digit morphogenesis
GO:0042770 signal transduction in response to DNA damage
GO:0043010 camera-type eye development
GO:0043029 T cell homeostasis
GO:0043254 regulation of protein complex assembly
GO:0043270 positive regulation of ion transport
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 regulation of protein binding
GO:0043473 pigmentation
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044270 cellular nitrogen compound catabolic process
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044773 mitotic DNA damage checkpoint
GO:0044774 mitotic DNA integrity checkpoint
GO:0044783 G1 DNA damage checkpoint
GO:0044801 single-organism membrane fusion
GO:0044819 mitotic G1/S transition checkpoint
GO:0044843 cell cycle G1/S phase transition
GO:0045136 development of secondary sexual characteristics
GO:0045137 development of primary sexual characteristics
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045862 positive regulation of proteolysis
GO:0045930 negative regulation of mitotic cell cycle
GO:0046545 development of primary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046651 lymphocyte proliferation
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0046666 retinal cell programmed cell death
GO:0046700 heterocycle catabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048050 post-embryonic eye morphogenesis
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048087 positive regulation of developmental pigmentation
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0048232 male gamete generation
GO:0048284 organelle fusion
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048515 spermatid differentiation
GO:0048563 post-embryonic animal organ morphogenesis
GO:0048569 post-embryonic animal organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048608 reproductive structure development
GO:0048678 response to axon injury
GO:0048732 gland development
GO:0048736 appendage development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048771 tissue remodeling
GO:0048806 genitalia development
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051402 neuron apoptotic process
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051881 regulation of mitochondrial membrane potential
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055074 calcium ion homeostasis
GO:0060011 Sertoli cell proliferation
GO:0060041 retina development in camera-type eye
GO:0060056 mammary gland involution
GO:0060057 apoptotic process involved in mammary gland involution
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060068 vagina development
GO:0060173 limb development
GO:0060249 anatomical structure homeostasis
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060443 mammary gland morphogenesis
GO:0060561 apoptotic process involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0061025 membrane fusion
GO:0061138 morphogenesis of a branching epithelium
GO:0061180 mammary gland epithelium development
GO:0061458 reproductive system development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070227 lymphocyte apoptotic process
GO:0070228 regulation of lymphocyte apoptotic process
GO:0070230 positive regulation of lymphocyte apoptotic process
GO:0070231 T cell apoptotic process
GO:0070242 thymocyte apoptotic process
GO:0070265 necrotic cell death
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070509 calcium ion import
GO:0070584 mitochondrion morphogenesis
GO:0070585 protein localization to mitochondrion
GO:0070588 calcium ion transmembrane transport
GO:0070661 leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0070997 neuron death
GO:0071156 regulation of cell cycle arrest
GO:0071158 positive regulation of cell cycle arrest
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0071593 lymphocyte aggregation
GO:0071887 leukocyte apoptotic process
GO:0072001 renal system development
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072395 signal transduction involved in cell cycle checkpoint
GO:0072401 signal transduction involved in DNA integrity checkpoint
GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
GO:0072422 signal transduction involved in DNA damage checkpoint
GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090068 positive regulation of cell cycle process
GO:0090150 establishment of protein localization to membrane
GO:0090199 regulation of release of cytochrome c from mitochondria
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090559 regulation of membrane permeability
GO:0090596 sensory organ morphogenesis
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097345 mitochondrial outer membrane permeabilization
GO:0097553 calcium ion transmembrane import into cytosol
GO:1900101 regulation of endoplasmic reticulum unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1900117 regulation of execution phase of apoptosis
GO:1900119 positive regulation of execution phase of apoptosis
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901361 organic cyclic compound catabolic process
GO:1901987 regulation of cell cycle phase transition
GO:1901988 negative regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902262 apoptotic process involved in patterning of blood vessels
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:1902337 regulation of apoptotic process involved in morphogenesis
GO:1902339 positive regulation of apoptotic process involved in morphogenesis
GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint
GO:1902402 signal transduction involved in mitotic DNA damage checkpoint
GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1902656 calcium ion import into cytosol
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1902742 apoptotic process involved in development
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903509 liposaccharide metabolic process
GO:1903519 regulation of mammary gland involution
GO:1903521 positive regulation of mammary gland involution
GO:1903624 regulation of DNA catabolic process
GO:1903626 positive regulation of DNA catabolic process
GO:1903894 regulation of IRE1-mediated unfolded protein response
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:1904747 positive regulation of apoptotic process involved in development
GO:1904748 regulation of apoptotic process involved in development
GO:1990117 B cell receptor apoptotic signaling pathway
GO:2000021 regulation of ion homeostasis
GO:2000027 regulation of organ morphogenesis
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000106 regulation of leukocyte apoptotic process
GO:2000108 positive regulation of leukocyte apoptotic process
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Molecular Function GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0046982 protein heterodimerization activity
GO:0051400 BH domain binding
GO:0051434 BH3 domain binding
GO:0070513 death domain binding
Cellular Component GO:0005635 nuclear envelope
GO:0005741 mitochondrial outer membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
GO:0046930 pore complex
GO:0097136 Bcl-2 family protein complex
GO:0097144 BAX complex
GO:0098798 mitochondrial protein complex
> KEGG and Reactome Pathway
 
KEGG hsa04071 Sphingolipid signaling pathway
hsa04115 p53 signaling pathway
hsa04141 Protein processing in endoplasmic reticulum
hsa04210 Apoptosis
hsa04722 Neurotrophin signaling pathway
Reactome R-HSA-114294: Activation, translocation and oligomerization of BAX
R-HSA-109581: Apoptosis
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-5357801: Programmed Cell Death
R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes
R-HSA-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BAX and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between BAX and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
10697273Central nervous system lymphomaInhibit immunityOverexpression of BCL-2, BCL-X, and BAX in primary central nervous system lymphomas that occur in immunosuppressed patients.
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BAX in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BAX in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0750.787
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.070.983
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0830.972
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1360.583
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2310.898
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0140.995
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2210.57
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.350.821
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1180.947
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7360.737
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8610.8
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0510.448
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BAX in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BAX. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BAX. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BAX.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BAX. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BAX expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BAX and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBAX
NameBCL2-associated X protein
Aliases BCL2L4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4 ......
Chromosomal Location19q13.3-q13.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BAX collected from DrugBank database.
> Drugs from DrugBank database
 

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