Browse BCLAF1

Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus. Nucleus speckle Nucleus, nucleoplasm
Domain PF15440 THRAP3/BCLAF1 family
Function

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

> Gene Ontology
 
Biological Process GO:0006352 DNA-templated transcription, initiation
GO:0031334 positive regulation of protein complex assembly
GO:0043254 regulation of protein complex assembly
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0044089 positive regulation of cellular component biogenesis
GO:0097193 intrinsic apoptotic signaling pathway
GO:2000142 regulation of DNA-templated transcription, initiation
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2001020 regulation of response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function -
Cellular Component GO:0016604 nuclear body
GO:0016607 nuclear speck
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BCLAF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BCLAF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BCLAF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0980.662
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.030.988
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1910.896
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0010.996
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1050.967
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1360.966
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1750.685
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1760.932
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2010.929
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2120.885
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9140.671
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0020.963
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BCLAF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.713.7-100.28
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.715.3-11.60.161
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117029.4-29.40.0123
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86033.3-33.30.165
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311027.3-27.30.0815
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.814.811
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.615.4-1.81
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.814.34.51
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BCLAF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BCLAF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BCLAF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BCLAF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BCLAF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BCLAF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBCLAF1
NameBCL2-associated transcription factor 1
Aliases KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1
Chromosomal Location6q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BCLAF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.