Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Nucleus speckle Nucleus, nucleoplasm |
Domain |
PF15440 THRAP3/BCLAF1 family |
Function |
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0031334 positive regulation of protein complex assembly GO:0043254 regulation of protein complex assembly GO:0043620 regulation of DNA-templated transcription in response to stress GO:0044089 positive regulation of cellular component biogenesis GO:0097193 intrinsic apoptotic signaling pathway GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway |
Molecular Function | - |
Cellular Component |
GO:0016604 nuclear body GO:0016607 nuclear speck |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BCLAF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of BCLAF1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BCLAF1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of BCLAF1 in various data sets.
|
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BCLAF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BCLAF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BCLAF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BCLAF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BCLAF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BCLAF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BCLAF1 |
Name | BCL2-associated transcription factor 1 |
Aliases | KIAA0164; BTF; bK211L9.1; Bcl-2-associated transcription factor 1 |
Chromosomal Location | 6q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BCLAF1 collected from DrugBank database. |
There is no record. |