Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane, postsynaptic density |
Domain |
PF09036 Bcr-Abl oncoprotein oligomerisation domain PF00168 C2 domain PF00620 RhoGAP domain PF00621 RhoGEF domain |
Function |
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. |
Biological Process |
GO:0001974 blood vessel remodeling GO:0002237 response to molecule of bacterial origin GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002283 neutrophil activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002446 neutrophil mediated immunity GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002686 negative regulation of leukocyte migration GO:0002691 regulation of cellular extravasation GO:0002692 negative regulation of cellular extravasation GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002886 regulation of myeloid leukocyte mediated immunity GO:0002887 negative regulation of myeloid leukocyte mediated immunity GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006887 exocytosis GO:0006909 phagocytosis GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007423 sensory organ development GO:0008015 blood circulation GO:0017157 regulation of exocytosis GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030100 regulation of endocytosis GO:0030336 negative regulation of cell migration GO:0031348 negative regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0034103 regulation of tissue remodeling GO:0034104 negative regulation of tissue remodeling GO:0035023 regulation of Rho protein signal transduction GO:0036230 granulocyte activation GO:0040013 negative regulation of locomotion GO:0042119 neutrophil activation GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0043114 regulation of vascular permeability GO:0043299 leukocyte degranulation GO:0043300 regulation of leukocyte degranulation GO:0043301 negative regulation of leukocyte degranulation GO:0043312 neutrophil degranulation GO:0043313 regulation of neutrophil degranulation GO:0043314 negative regulation of neutrophil degranulation GO:0043583 ear development GO:0045055 regulated exocytosis GO:0045123 cellular extravasation GO:0045807 positive regulation of endocytosis GO:0045920 negative regulation of exocytosis GO:0046578 regulation of Ras protein signal transduction GO:0046777 protein autophosphorylation GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048771 tissue remodeling GO:0048839 inner ear development GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050777 negative regulation of immune response GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050885 neuromuscular process controlling balance GO:0050900 leukocyte migration GO:0050905 neuromuscular process GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051056 regulation of small GTPase mediated signal transduction GO:0051271 negative regulation of cellular component movement GO:0060312 regulation of blood vessel remodeling GO:0060313 negative regulation of blood vessel remodeling GO:0060627 regulation of vesicle-mediated transport GO:0090596 sensory organ morphogenesis GO:1902563 regulation of neutrophil activation GO:1902564 negative regulation of neutrophil activation GO:1903305 regulation of regulated secretory pathway GO:1903306 negative regulation of regulated secretory pathway GO:1903531 negative regulation of secretion by cell GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004713 protein tyrosine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0030695 GTPase regulator activity GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0014069 postsynaptic density GO:0045211 postsynaptic membrane GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG | - |
Reactome |
R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-1226099: Signaling by FGFR in disease R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-194315: Signaling by Rho GTPases R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants |
Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BCR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between BCR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BCR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BCR in various data sets.
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Points in the above scatter plot represent the mutation difference of BCR in various data sets.
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Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BCR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BCR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BCR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BCR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BCR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BCR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | BCR |
Name | breakpoint cluster region |
Aliases | D22S662; CML; PHL; ALL; D22S11; BCR1; ALL1; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carc ...... |
Chromosomal Location | 22q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BCR collected from DrugBank database. |
Details on drugs targeting BCR.
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