Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion inner membrane Mitochondrion matrix |
Domain |
PF00106 short chain dehydrogenase |
Function |
- |
Biological Process |
GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046950 cellular ketone body metabolic process GO:0046951 ketone body biosynthetic process GO:0046952 ketone body catabolic process GO:1902224 ketone body metabolic process |
Molecular Function |
GO:0003858 3-hydroxybutyrate dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0044455 mitochondrial membrane part GO:0098552 side of membrane GO:0098576 lumenal side of membrane GO:0099617 matrix side of mitochondrial inner membrane |
KEGG |
hsa00072 Synthesis and degradation of ketone bodies hsa00650 Butanoate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74182: Ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-77111: Synthesis of Ketone Bodies R-HSA-77108: Utilization of Ketone Bodies |
Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BDH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BDH1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BDH1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BDH1 in various data sets.
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Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BDH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BDH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BDH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BDH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BDH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BDH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BDH1 |
Name | 3-hydroxybutyrate dehydrogenase, type 1 |
Aliases | SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BDH1 collected from DrugBank database. |
Details on drugs targeting BDH1.
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