Browse BDH1

Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion inner membrane Mitochondrion matrix
Domain PF00106 short chain dehydrogenase
Function

-

> Gene Ontology
 
Biological Process GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0046950 cellular ketone body metabolic process
GO:0046951 ketone body biosynthetic process
GO:0046952 ketone body catabolic process
GO:1902224 ketone body metabolic process
Molecular Function GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Cellular Component GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0044455 mitochondrial membrane part
GO:0098552 side of membrane
GO:0098576 lumenal side of membrane
GO:0099617 matrix side of mitochondrial inner membrane
> KEGG and Reactome Pathway
 
KEGG hsa00072 Synthesis and degradation of ketone bodies
hsa00650 Butanoate metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74182: Ketone body metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-77111: Synthesis of Ketone Bodies
R-HSA-77108: Utilization of Ketone Bodies
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BDH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BDH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BDH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4530.368
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1040.948
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.7230.472
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7480.029
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8020.617
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6810.741
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.190.636
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1740.884
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1870.884
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4340.758
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4780.791
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1150.478
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BDH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BDH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BDH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BDH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BDH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BDH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BDH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBDH1
Name3-hydroxybutyrate dehydrogenase, type 1
Aliases SDR9C1; short chain dehydrogenase/reductase family 9C, member 1; BDH; 3-hydroxybutyrate dehydrogenase (heart ......
Chromosomal Location3q29
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BDH1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting BDH1.
ID Name Drug Type Targets #Targets
DB00157NADHSmall MoleculeAASS, ACADS, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH7, AKR1B1, AKR1C1 ......144