Browse BECN1

Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein Endosome membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Mitochondrion membrane Peripheral membrane protein Endosome Cytoplasmic vesicle, autophagosome Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). ; SUBCELLULAR LOCATION: Beclin-1-C 35 kDa: Mitochondrion Nucleus Cytoplasm ; SUBCELLULAR LOCATION: Beclin-1-C 37 kDa: Mitochondrion
Domain PF04111 Autophagy protein Apg6
PF15285 Beclin-1 BH3 domain
Function

Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. ; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000070 mitotic sister chromatid segregation
GO:0000422 mitophagy
GO:0000423 macromitophagy
GO:0000819 sister chromatid segregation
GO:0000910 cytokinesis
GO:0001666 response to hypoxia
GO:0006623 protein targeting to vacuole
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0006914 autophagy
GO:0006968 cellular defense response
GO:0006995 cellular response to nitrogen starvation
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007040 lysosome organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0007088 regulation of mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
GO:0007584 response to nutrient
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0009267 cellular response to starvation
GO:0009615 response to virus
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010044 response to aluminum ion
GO:0010324 membrane invagination
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0032258 CVT pathway
GO:0032465 regulation of cytokinesis
GO:0032801 receptor catabolic process
GO:0033044 regulation of chromosome organization
GO:0033045 regulation of sister chromatid segregation
GO:0033047 regulation of mitotic sister chromatid segregation
GO:0033197 response to vitamin E
GO:0033273 response to vitamin
GO:0036293 response to decreased oxygen levels
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043112 receptor metabolic process
GO:0043277 apoptotic cell clearance
GO:0043562 cellular response to nitrogen levels
GO:0043652 engulfment of apoptotic cell
GO:0044804 nucleophagy
GO:0045324 late endosome to vacuole transport
GO:0045787 positive regulation of cell cycle
GO:0045840 positive regulation of mitotic nuclear division
GO:0045931 positive regulation of mitotic cell cycle
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0050000 chromosome localization
GO:0050435 beta-amyloid metabolic process
GO:0051302 regulation of cell division
GO:0051303 establishment of chromosome localization
GO:0051310 metaphase plate congression
GO:0051315 attachment of mitotic spindle microtubules to kinetochore
GO:0051607 defense response to virus
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0051983 regulation of chromosome segregation
GO:0051984 positive regulation of chromosome segregation
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0061726 mitochondrion disassembly
GO:0070482 response to oxygen levels
GO:0070849 response to epidermal growth factor
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071275 cellular response to aluminum ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071496 cellular response to external stimulus
GO:0072593 reactive oxygen species metabolic process
GO:0072665 protein localization to vacuole
GO:0072666 establishment of protein localization to vacuole
GO:0080171 lytic vacuole organization
GO:0090068 positive regulation of cell cycle process
GO:0090235 regulation of metaphase plate congression
GO:0098542 defense response to other organism
GO:0098779 mitophagy in response to mitochondrial depolarization
GO:0098780 response to mitochondrial depolarisation
GO:0098813 nuclear chromosome segregation
GO:0099024 plasma membrane invagination
GO:1902423 regulation of mitotic attachment of spindle microtubules to kinetochore
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903008 organelle disassembly
GO:1903146 regulation of mitophagy
GO:1903599 positive regulation of mitophagy
GO:1905037 autophagosome organization
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2001252 positive regulation of chromosome organization
Molecular Function GO:0031625 ubiquitin protein ligase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044389 ubiquitin-like protein ligase binding
Cellular Component GO:0000407 pre-autophagosomal structure
GO:0005776 autophagosome
GO:0005802 trans-Golgi network
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0010008 endosome membrane
GO:0019898 extrinsic component of membrane
GO:0030139 endocytic vesicle
GO:0030425 dendrite
GO:0031984 organelle subcompartment
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II
GO:0035032 phosphatidylinositol 3-kinase complex, class III
GO:0044440 endosomal part
GO:0045335 phagocytic vesicle
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-5688426: Deubiquitination
R-HSA-1632852: Macroautophagy
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-5689880: Ub-specific processing proteases
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BECN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between BECN1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29368981MelanomaInhibit immunity (NK cell infiltration)Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield. We showed that genetic targeting of the macroautophagy/autophagy gene Becn1/Beclin1 in B16-F10 tumors inhibits their growth by inducing a massive infiltration of functional natural killer (NK) cells into the tumor bed.
23635487Breast CarcinomaInhibit immunity (T cell function)Silencing of BECN1 in target cells that have gone through the EMT restored CTL susceptibility to CTL-induced lysis.
29616191breast carcinomaInhibit immunityGenetic inactivation of Beclin-1, an autophagy regulator, significantly reverses mitochondrial abnormalities and tumor development in ATM-null mice, independently of DDR.
24101526Breast CarcinomaInhibit immunityInhibition of autophagy by targeting beclin1 (BECN1) restored granzyme B levels in hypoxic cells in vitro and induced tumor regression in vivo by facilitating NK-mediated tumor cell killing.
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BECN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.61; FDR: 0.04170 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BECN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4520.0244
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6020.808
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3480.841
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4010.208
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0160.993
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8880.722
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0790.825
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2070.893
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1230.946
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0980.958
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6460.815
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0380.473
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BECN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BECN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BECN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BECN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BECN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BECN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BECN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBECN1
Namebeclin 1, autophagy related
Aliases ATG6; VPS30; ATG6 autophagy related 6 homolog (S. cerevisiae); beclin 1 (coiled-coil, moesin-like BCL2 inter ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BECN1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting BECN1.
ID Name Drug Type Targets #Targets
DB00783EstradiolSmall MoleculeBECN1, CHRNA4, ESR1, ESR2, ESRRG, GPER1, HSD17B2, MT-ATP6, NCOA2, ......10
DB13952Estradiol acetateSmall MoleculeBECN1, CHRNA4, ESR1, ESR2, ESRRG, GPER1, HSD17B2, MT-ATP6, NCOA2, ......10
DB13953Estradiol benzoateSmall MoleculeBECN1, CHRNA4, ESR1, ESR2, ESRRG, GPER1, HSD17B2, MT-ATP6, NCOA2, ......10
DB13954Estradiol cypionateSmall MoleculeBECN1, CHRNA4, ESR1, ESR2, ESRRG, GPER1, HSD17B2, MT-ATP6, NCOA2, ......10
DB13955Estradiol dienanthateSmall MoleculeBECN1, CHRNA4, ESR1, ESR2, ESRRG, GPER1, HSD17B2, MT-ATP6, NCOA2, ......10
DB13956Estradiol valerateSmall MoleculeBECN1, CHRNA4, ESR1, ESR2, ESRRG, GPER1, HSD17B2, MT-ATP6, NCOA2, ......10