Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm, cytoskeleton Cytoplasm, cell cortex Note=Detected adjacent to the cell membrane. |
Domain |
PF00038 Intermediate filament protein |
Function |
Involved in stabilization of lens fiber cell cytoskeleton. |
Biological Process |
GO:0001654 eye development GO:0002064 epithelial cell development GO:0002088 lens development in camera-type eye GO:0007423 sensory organ development GO:0007601 visual perception GO:0021700 developmental maturation GO:0043010 camera-type eye development GO:0045103 intermediate filament-based process GO:0045104 intermediate filament cytoskeleton organization GO:0048469 cell maturation GO:0050953 sensory perception of light stimulus GO:0070306 lens fiber cell differentiation GO:0070307 lens fiber cell development |
Molecular Function |
GO:0005200 structural constituent of cytoskeleton GO:0005212 structural constituent of eye lens |
Cellular Component |
GO:0005882 intermediate filament GO:0005938 cell cortex GO:0045111 intermediate filament cytoskeleton GO:0099568 cytoplasmic region |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BFSP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BFSP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BFSP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of BFSP2 in various data sets.
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Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BFSP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BFSP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BFSP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BFSP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BFSP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BFSP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BFSP2 |
Name | beaded filament structural protein 2, phakinin |
Aliases | CP47; CP49; LIFL-L; phakinin; CTRCT12; PHAKOSIN; 49 kDa cytoskeletal protein; beaded filament protein CP49; ...... |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BFSP2 collected from DrugBank database. |
There is no record. |