Browse BHMT2

Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF02574 Homocysteine S-methyltransferase
Function

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.

> Gene Ontology
 
Biological Process GO:0000096 sulfur amino acid metabolic process
GO:0006520 cellular amino acid metabolic process
GO:0006555 methionine metabolic process
GO:0006732 coenzyme metabolic process
GO:0006790 sulfur compound metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009066 aspartate family amino acid metabolic process
GO:0009067 aspartate family amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0016053 organic acid biosynthetic process
GO:0032259 methylation
GO:0033477 S-methylmethionine metabolic process
GO:0043094 cellular metabolic compound salvage
GO:0043102 amino acid salvage
GO:0044283 small molecule biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046500 S-adenosylmethionine metabolic process
GO:0051186 cofactor metabolic process
GO:0071265 L-methionine biosynthetic process
GO:0071267 L-methionine salvage
GO:1901605 alpha-amino acid metabolic process
GO:1901607 alpha-amino acid biosynthetic process
Molecular Function GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00270 Cysteine and methionine metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-1614635: Sulfur amino acid metabolism
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BHMT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BHMT2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BHMT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.220.707
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2130.828
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5480.487
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2650.707
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4420.777
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1590.543
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.090.905
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8250.439
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.280.267
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0540.981
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.630.847
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8790.000582
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BHMT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BHMT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BHMT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BHMT2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BHMT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BHMT2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BHMT2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBHMT2
Namebetaine--homocysteine S-methyltransferase 2
Aliases SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ......
Chromosomal Location5q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BHMT2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting BHMT2.
ID Name Drug Type Targets #Targets
DB00134MethionineSmall MoleculeBHMT, BHMT2, METAP2, MTR, MTRR5