Summary | |
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Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF02574 Homocysteine S-methyltransferase |
Function |
Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. |
Biological Process |
GO:0000096 sulfur amino acid metabolic process GO:0006520 cellular amino acid metabolic process GO:0006555 methionine metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0008652 cellular amino acid biosynthetic process GO:0009066 aspartate family amino acid metabolic process GO:0009067 aspartate family amino acid biosynthetic process GO:0009086 methionine biosynthetic process GO:0016053 organic acid biosynthetic process GO:0032259 methylation GO:0033477 S-methylmethionine metabolic process GO:0043094 cellular metabolic compound salvage GO:0043102 amino acid salvage GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046500 S-adenosylmethionine metabolic process GO:0051186 cofactor metabolic process GO:0071265 L-methionine biosynthetic process GO:0071267 L-methionine salvage GO:1901605 alpha-amino acid metabolic process GO:1901607 alpha-amino acid biosynthetic process |
Molecular Function |
GO:0008168 methyltransferase activity GO:0008172 S-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity |
Cellular Component | - |
KEGG |
hsa00270 Cysteine and methionine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-1614635: Sulfur amino acid metabolism |
Summary | |
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Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BHMT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BHMT2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BHMT2 in various data sets.
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Points in the above scatter plot represent the mutation difference of BHMT2 in various data sets.
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Summary | |
---|---|
Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BHMT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BHMT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BHMT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BHMT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BHMT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BHMT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BHMT2 |
Name | betaine--homocysteine S-methyltransferase 2 |
Aliases | SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; S-methylmethionine--homocysteine S-meth ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BHMT2 collected from DrugBank database. |
Details on drugs targeting BHMT2.
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