Browse BICD1

Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus.
Domain PF09730 Microtubule-associated protein Bicaudal-D
Function

Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0006403 RNA localization
GO:0006898 receptor-mediated endocytosis
GO:0007018 microtubule-based movement
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008298 intracellular mRNA localization
GO:0010469 regulation of receptor activity
GO:0010517 regulation of phospholipase activity
GO:0010519 negative regulation of phospholipase activity
GO:0010970 transport along microtubule
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0030100 regulation of endocytosis
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0034063 stress granule assembly
GO:0034453 microtubule anchoring
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045807 positive regulation of endocytosis
GO:0048259 regulation of receptor-mediated endocytosis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0051346 negative regulation of hydrolase activity
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0060191 regulation of lipase activity
GO:0060192 negative regulation of lipase activity
GO:0060627 regulation of vesicle-mediated transport
GO:0071826 ribonucleoprotein complex subunit organization
GO:0072384 organelle transport along microtubule
GO:0072385 minus-end-directed organelle transport along microtubule
GO:0072393 microtubule anchoring at microtubule organizing center
GO:1900274 regulation of phospholipase C activity
GO:1900275 negative regulation of phospholipase C activity
GO:1900276 regulation of proteinase activated receptor activity
GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
GO:1900737 negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005200 structural constituent of cytoskeleton
GO:0008093 cytoskeletal adaptor activity
GO:0017016 Ras GTPase binding
GO:0017137 Rab GTPase binding
GO:0030674 protein binding, bridging
GO:0031267 small GTPase binding
GO:0031871 proteinase activated receptor binding
GO:0034452 dynactin binding
GO:0045502 dynein binding
GO:0051020 GTPase binding
GO:0060090 binding, bridging
Cellular Component GO:0005802 trans-Golgi network
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0018995 host
GO:0030430 host cell cytoplasm
GO:0031984 organelle subcompartment
GO:0033643 host cell part
GO:0033646 host intracellular part
GO:0033647 host intracellular organelle
GO:0033648 host intracellular membrane-bounded organelle
GO:0033655 host cell cytoplasm part
GO:0039713 viral factory
GO:0039714 cytoplasmic viral factory
GO:0043656 intracellular region of host
GO:0043657 host cell
GO:0044215 other organism
GO:0044216 other organism cell
GO:0044217 other organism part
GO:0045298 tubulin complex
GO:0072517 host cell viral assembly compartment
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-6811436: COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BICD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BICD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BICD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0940.784
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5910.576
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2630.719
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0550.817
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0740.968
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0280.991
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0310.934
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1180.924
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3160.796
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.160.899
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0990.957
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2480.0224
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BICD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.81.413.40.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.81.713.10.032
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BICD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BICD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BICD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BICD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BICD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BICD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBICD1
Namebicaudal D homolog 1 (Drosophila)
Aliases Bicaudal D (Drosophila) homolog 1; BICD; bic-D 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bi ......
Chromosomal Location12p11.2-p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BICD1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.