Summary | |
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Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform BIN1: Nucleus.; SUBCELLULAR LOCATION: Isoform IIA: Cytoplasm. |
Domain |
PF03114 BAR domain PF14604 Variant SH3 domain |
Function |
May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation. |
Biological Process |
GO:0006997 nucleus organization GO:0007050 cell cycle arrest GO:0010001 glial cell differentiation GO:0010720 positive regulation of cell development GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0030100 regulation of endocytosis GO:0042063 gliogenesis GO:0042692 muscle cell differentiation GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045786 negative regulation of cell cycle GO:0048708 astrocyte differentiation GO:0048710 regulation of astrocyte differentiation GO:0048711 positive regulation of astrocyte differentiation GO:0050769 positive regulation of neurogenesis GO:0051640 organelle localization GO:0051647 nucleus localization GO:0051962 positive regulation of nervous system development GO:0060627 regulation of vesicle-mediated transport GO:0060988 lipid tube assembly GO:0065005 protein-lipid complex assembly GO:0071156 regulation of cell cycle arrest GO:0071825 protein-lipid complex subunit organization |
Molecular Function |
GO:0003779 actin binding GO:0048156 tau protein binding GO:0051015 actin filament binding GO:0070063 RNA polymerase binding |
Cellular Component |
GO:0005635 nuclear envelope GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0030315 T-tubule GO:0030424 axon GO:0031674 I band GO:0032994 protein-lipid complex GO:0033267 axon part GO:0033268 node of Ranvier GO:0042383 sarcolemma GO:0043194 axon initial segment GO:0043292 contractile fiber GO:0044304 main axon GO:0044449 contractile fiber part GO:0060987 lipid tube |
KEGG |
hsa04144 Endocytosis hsa04666 Fc gamma R-mediated phagocytosis |
Reactome |
R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BIN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between BIN1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BIN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BIN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BIN1 in various data sets.
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Summary | |
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Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BIN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BIN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BIN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BIN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BIN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BIN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BIN1 |
Name | bridging integrator 1 |
Aliases | SH3P9; AMPH2; amphiphysin II; AMPHL; amphiphysin-like protein; box dependant MYC interacting protein 1; box- ...... |
Chromosomal Location | 2q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BIN1 collected from DrugBank database. |
There is no record. |