Summary | |
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Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF09166 Biliverdin reductase PF01408 Oxidoreductase family |
Function |
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. |
Biological Process |
GO:0006778 porphyrin-containing compound metabolic process GO:0006787 porphyrin-containing compound catabolic process GO:0019439 aromatic compound catabolic process GO:0033013 tetrapyrrole metabolic process GO:0033015 tetrapyrrole catabolic process GO:0042167 heme catabolic process GO:0042168 heme metabolic process GO:0042440 pigment metabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046149 pigment catabolic process GO:0046700 heterocycle catabolic process GO:0051186 cofactor metabolic process GO:0051187 cofactor catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0004074 biliverdin reductase activity GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
Cellular Component | - |
KEGG |
hsa00860 Porphyrin and chlorophyll metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-189483: Heme degradation R-HSA-1430728: Metabolism R-HSA-189445: Metabolism of porphyrins |
Summary | |
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Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BLVRA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BLVRA in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BLVRA in various data sets.
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Points in the above scatter plot represent the mutation difference of BLVRA in various data sets.
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Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BLVRA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BLVRA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BLVRA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BLVRA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BLVRA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BLVRA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BLVRA |
Name | biliverdin reductase A |
Aliases | BLVR; BVR; BVRA; BVR A; biliverdin-IX alpha-reductase |
Chromosomal Location | 7p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BLVRA collected from DrugBank database. |
Details on drugs targeting BLVRA.
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